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    1. Neuroscience

    Machine Learning Based Modelling of Human and Insect Olfaction Screens Millions of compounds to Identify Pleasant Smelling Insect Repellents

    Joel Kowalewski, Sean M. Boyle ... Anandasankar Ray
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

    Ana Milovic, Jonathan V Duong, Alan G Barbour
    Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.
    1. Neuroscience

    Aminergic and peptidergic modulation of Insulin-Producing Cells in Drosophila

    Martina Held, Rituja S Bisen ... Jan M Ache
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience
    2. Ecology

    Machine learning of honey bee olfactory behavior identifies repellent odorants in free flying bees in the field

    Joel Kowalewski, Barbara Baer-Imhoof ... Anandasankar Ray
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females

    Bretta Hixson, Xiao-Li Bing ... Nicolas Buchon
    RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.
    1. Epidemiology and Global Health

    Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset

    Ariel Karlinsky, Dmitry Kobak
    The World Mortality Dataset and paper is the largest dataset of all-cause mortality currently in existence for tracking mortality and excess mortality during the COVID-19 pandemic.
    1. Genetics and Genomics

    Targeting sex determination to suppress mosquito populations

    Ming Li, Nikolay P Kandul ... Omar S Akbari
    Genetic analyses and mathematical modeling reveal that disrupting genes essential for sex determination and fertility in Aedes aegypti leads to the production of sterile males, effectively suppressing mosquito populations.
    1. Medicine
    2. Cancer Biology

    Development and Assessment of a Sustainable PhD Internship Program Supporting Diverse Biomedical Career Outcomes

    Patrick D Brandt, Dawayne Whittington ... Rebekah L Layton
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

    Dihia Moussaoui, James P Robblee ... Anne Houdusse
    The structure of full-length myosin A provides some hints about its atypical mechanism, and reveals that the light chain PfELC is a target to block malaria pathogenesis.