Nuanced changes in the mechanism of oscillation in reciprocally inhibitory circuits can profoundly alter the circuit stability in response to perturbations and inputs.
Carlos-Henrique D Barbosa, Fábio B Canto ... Maria Bellio
Cytotoxic CD4 T lymphocytes are abundantly generated in T. cruzi-infected mice, predominantly infiltrate infected hearts, depend on T-cell intrinsic IL-18R/MyD88 signaling for expansion and their blood frequency correlates with the severity of chronic myocarditis in patients with Chagas disease.
There are fundamental limits to what can be learned about the origins of transcriptional noise from gene expression data alone, which can be overcome by simultaneously quantifying the abundances of linked molecular species.
The C9orf72 expansion binds and sequesters the splicing factor hnRNP H leading to insoluble G-quadruplex aggregates that functionally reduce hnRNP H, thereby producing splicing defects.
Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.
Giancarlo Cicconofri, Giovanni Noselli, Antonio DeSimone
The 'spinning lasso' geometry of Euglena's beating flagellum is revealed, and a model based on the antagonistic forces exchanged by axoneme and paraflagellar rod is proposed to explain its emergence.
Radhika A Varier, Theodora Sideri ... Folkert J van Werven
N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.
Nicolai J Toft, Trine V Axelsen ... Ebbe Boedtkjer
Cellular acidity, capacity for net acid extrusion, and expression of acid-base transporters in human breast carcinomas independently predict variation in proliferative activity, lymph node metastasis, and patient survival.
Xiaochen Fan, V Pragathi Masamsetti ... Patrick PL Tam
Network propagation connects TWIST1 with epigenetic regulators CHD7, CHD8, and WHSC1, which collectively promote the bias toward neural crest while suppressing neural stem cell programmes, and subsequently enhance ectomesenchyme potential.
Prefrontal cortex plays a leading role in sequential decisions compared to posterior parietal cortex and relies on nonlinear integration of sensory and mnemonic information for decision formation.
