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    1. Evolutionary Biology
    2. Medicine

    APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

    Angela R Garcia, Caleb Finch ... Benjamin C Trumble
    The relationship between APOE genotype and disease risks may be environmentally moderated, with APOE4 being less harmful and unlikely to increase cardiometabolic risk in a physically active, energy-limited population.
    1. Epidemiology and Global Health

    Local human movement patterns and land use impact exposure to zoonotic malaria in Malaysian Borneo

    Kimberly M Fornace, Neal Alexander ... Chris Drakeley
    Local human movement into mosquito habitats around forest edges intensifies interactions between pathogens, insects and people, increasing exposure risks to the zoonotic malaria Plasmodium knowlesi in Malaysian Borneo.
    1. Neuroscience

    Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

    Dennis London, Arash Fazl ... Roozbeh Kiani
    Subthalamic nucleus spiking activity, beta oscillation power, and locking of spikes to the beta oscillation are decreased prior to changes in ongoing movements.
  1. Webinar Report: The Languages of Science – multilingual science communication awareness

    Watch back as our speakers introduce the importance of multilingual science communication and discuss solutions to embracing all languages within our global research community.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Mapping global environmental suitability for Zika virus

    Jane P Messina, Moritz UG Kraemer ... Simon I Hay
    A global map of environmental suitability for Zika virus and the estimated population living at potential risk can help refine public health guidelines, travel advisories and intervention strategies at a crucial time in the global emergence of this arbovirus.
    1. Ecology

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle, Christian R Boehm ... William J Sutherland
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site

    Matthew T Parker, Beth K Soanes ... Gordon G Simpson
    High throughput sequencing of Arabidopsis mutants lacking the U6 snRNA methyltransferase FIONA1/METTL16 uncovers the role of U6 methylation in splicing signal preferences.
    1. Biochemistry and Chemical Biology

    Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

    Tomomi Hashidate-Yoshida, Takeshi Harayama ... Takao Shimizu
    LPCAT3 incorporates arachidonic acid into membrane phospholipids, which promotes lipoprotein assembly by enabling triacylgylcerols to cluster in the membrane.
    1. Biochemistry and Chemical Biology
    2. Epidemiology and Global Health

    Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study

    Takashi Sasaki, Yoshinori Nishimoto ... Yasumichi Arai
    Circulating high-molecular-weight (cHMW) adiponectin levels increased with age until centenarians, and the contribution of known major factors associated with cHMW adiponectin levels including BMI varied with age, suggesting that its physiological significance also varies with age in the oldest old.
    1. Microbiology and Infectious Disease

    A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

    Manabu Aoki, Hironori Hayashi ... Hiroaki Mitsuya
    GRL-142 is an HIV protease inhibitor with a unique structure and atto-to-picomolar potency against a wide range of HIV strains.