Class 1 histone deacetylase (HDAC) inhibitor MS-275 enhances the efficacy of glucagon-like peptide 1 receptor (GLP-1R) therapy for glycemic control and reduction of obesity.

Contrary to previous reports, a complete absence of glucagon signaling is not sufficient to prevent diabetes after near-total β-cell loss.

Two functionally antagonizing groups of hormones directly regulate starvation-induced increase in locomotion via a common neural target in fruit flies.

A subset of hypothalamic POMC neurons that express leptin receptors control metabolic responses to changing energy availability including regulating blood glucose and leptin levels.

The diffusional barrier formed between phagocyte integrin and fungal glucans preserves the microbiostatic phagocytic environment generated during the frustrated phagocytosis of Candida albicans hypha.

Lateral septum neurotensin neurons are active in response to stress where escape is a viable strategy and decrease consumption via effects on hypothalamic pathways regulating food intake.

The structure provides key insights into hormone recognition and activation of the glucose-dependent insulinotropic polypeptide receptor.

Extracellular actin is an evolutionarily-conserved signal of tissue injury that is recognised in the fruit fly via similar machinery as reported in vertebrates.

Pancreatic α and β cells have different cell autonomous signatures; this explains why α but not β cells can clear infections by potentially diabetogenic viruses.