Contrary to previous reports, a complete absence of glucagon signaling is not sufficient to prevent diabetes after near-total β-cell loss.

Class 1 histone deacetylase (HDAC) inhibitor MS-275 enhances the efficacy of glucagon-like peptide 1 receptor (GLP-1R) therapy for glycemic control and reduction of obesity.

The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.

A subset of hypothalamic POMC neurons that express leptin receptors control metabolic responses to changing energy availability including regulating blood glucose and leptin levels.

A genetically encoded sensor and a photocaged peptide together enable precise investigation of human glucagon-like peptide-1 receptor activation with high spatiotemporal resolution.

Two functionally antagonizing groups of hormones directly regulate starvation-induced increase in locomotion via a common neural target in fruit flies.

A novel process by which counter-regulatory glucagon release is regulated in both mouse and human.

Hepatic TAZ coordinates the differential expression of gluconeogenic genes in the fasted and fed states by inhibiting glucocorticoid receptor.