670 results found
    1. Developmental Biology

    Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists

    Sri Teja Mullapudi et al.
    Zebrafish insulin mutants serve as an innovative platform to identify novel mechanisms regulating glucose homeostasis.
    1. Neuroscience

    Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

    Sophie Croizier et al.
    Loss miRNA maturation in proopiomelanocortin (POMC) neurons causes metabolic dysregulation and favors the differentiation of Pomc progenitors into neuropeptide Y neurons, a developmental process that appears to specifically involve miR-103/107.
    1. Cell Biology

    PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

    Insook Jang et al.
    The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.
    1. Developmental Biology

    Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature

    Alexis M Ceasrine et al.
    β2-adrenergic receptors control glucose metabolism by regulating cross-talk between pancreatic islet endocrine cells and vasculature during development.
    1. Human Biology and Medicine

    Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

    Nicolas Damond et al.
    Contrary to previous reports, a complete absence of glucagon signaling is not sufficient to prevent diabetes after near-total β-cell loss.
    1. Human Biology and Medicine
    2. Neuroscience

    POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

    Alexandre Caron et al.
    A subset of hypothalamic POMC neurons that express leptin receptors control metabolic responses to changing energy availability including regulating blood glucose and leptin levels.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction

    Rebeccah J Katzenberger et al.
    Use of a newly developed experimental model in fruit flies reveals that death following traumatic brain injury is largely due to a mechanism by which brain damage triggers disruption of the intestinal barrier, leading to elevated levels of glucose in the circulatory system with deleterious consequences.
    1. Human Biology and Medicine

    Increase in clinically recorded type 2 diabetes after colectomy

    Anders B Jensen et al.
    This nationwide register-based study of diabetes risk after colectomy suggests that the left colon contributes to maintenance of glucose homeostasis.
    1. Cell Biology
    2. Human Biology and Medicine

    Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

    Martina Rudnicki et al.
    Stimulation of endothelial glucose metabolism and vascular growth by genetic depletion of endothelial Foxo1 improves the whole-body response to a high-fat diet, by preserving adipose tissue functions and glucose homeostasis.
    1. Human Biology and Medicine

    Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

    Laurent Perrin et al.
    Rhythmic transcriptome analyses of human skeletal muscle tissue and cultured primary myotubes reveal an essential role for the circadian coordination of glucose homeostasis and lipid metabolism in human skeletal muscle.

Refine your results by:

Type
Research categories