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    1. Cell Biology

    Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

    Laurent Perrin, Ursula Loizides-Mangold ... Charna Dibner
    Rhythmic transcriptome analyses of human skeletal muscle tissue and cultured primary myotubes reveal an essential role for the circadian coordination of glucose homeostasis and lipid metabolism in human skeletal muscle.
    1. Neuroscience

    POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

    Alexandre Caron, Heather M Dungan Lemko ... Joel K Elmquist
    A subset of hypothalamic POMC neurons that express leptin receptors control metabolic responses to changing energy availability including regulating blood glucose and leptin levels.
    1. Cell Biology

    High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast

    Masak Takaine, Hiromi Imamura, Satoshi Yoshida
    The first demonstration that cellular ATP homeostasis suppresses high volatility of cellular ATP levels to ensure proteostasis that prevents accumulation of cytotoxic protein aggregation.
    1. Medicine

    Increase in clinically recorded type 2 diabetes after colectomy

    Anders B Jensen, Thorkild IA Sørensen ... Kristine H Allin
    This nationwide register-based study of diabetes risk after colectomy suggests that the left colon contributes to maintenance of glucose homeostasis.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

    Ritu Gupta, Adhish S Walvekar ... Sunil Laxman
    The role of an amino acid-dependent tRNA modification as a nutrient sensor and regulator of metabolic homeostasis has been discovered.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults

    William E Barry, Carl S Thummel
    Drosophila HNF4 directs a developmental switch at the onset of adulthood that suppresses diabetes by promoting mitochondrial function and supporting glucose-stimulated insulin secretion.
    1. Medicine

    The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

    Karla J Suchacki, Benjamin J Thomas ... William P Cawthorn
    The health benefits of caloric restriction, including decreasing body fat and blood glucose, differ between males and females and this difference depends on the age at which caloric restriction begins.
    1. Cell Biology

    KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

    Anthony A Ruberto, Aline Gréchez-Cassiau ... Michèle Teboul
    Krüppel-like factor 10 coordinates the hepatic circadian transcriptome and protects the liver from the adverse effects of increased sugar consumption.
    1. Microbiology and Infectious Disease

    Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

    Somnath Shee, Reshma T Veetil ... Amit Singh
    Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.
    1. Cell Biology
    2. Developmental Biology

    Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

    Jeongkyung Lee, Ruya Liu ... Vijay K. Yechoor
    Not revised
    Reviewed Preprint v1
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