1,059 results found
    1. Microbiology and Infectious Disease

    Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping

    Philip P Adams et al.
    Multiple RNA-seq approaches globally mapped RNA 3´ ends resulting in the discovery of numerous and diverse RNA regulators.
    1. Immunology and Inflammation
    2. Medicine

    The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

    Danielle Janosevic et al.
    Single-cell RNA-sequencing identifies the precise cellular and molecular events that occur along the sepsis timeline in the kidney, pointing to potential biomarkers and therapeutic targets.
    1. Structural Biology and Molecular Biophysics

    ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels

    Adishesh K Narahari et al.
    Purified Pannexin 1 channels activated by caspase cleavage in proteoliposomes reconstitute a permeation pathway for intercellular signaling molecules important in inflammation and cell clearance.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Salah A Baker et al.
    An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca2+ signaling.
    1. Cancer Biology

    MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

    Tessa M Popay et al.
    Interaction of oncoprotein transcription factor MYC with chromatin-associated protein host cell factor–1 controls expression of genes important for ribosome biogenesis and mitochondrial vigor, loss of which promotes tumor regression.
    1. Evolutionary Biology

    Constitutive activation of cellular immunity underlies the evolution of resistance to infection in Drosophila

    Alexandre B Leitão et al.
    Single-cell transcriptomics of immune cells demonstrates that populations evolve inducible defences when infection rates are low and constitutive defences when infection is common.
    1. Chromosomes and Gene Expression

    Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling

    Seunghee Oh et al.
    Yeast Nuak1 is an AMPK and CK2 dependent H3 T11 kinase.
    1. Evolutionary Biology
    2. Medicine

    Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

    Antonis Rokas et al.
    This review considers the evolutionary processes and physiological mechanisms that maintain or end pregnancy in mammals to formulate general, testable theoretical models that provide insights into the biology of parturition.
    1. Cell Biology
    2. Medicine

    Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

    Jin Rong Ow et al.
    Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
    1. Cell Biology

    Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2

    Benjamin M Adams et al.
    Natural substrates of the central endoplasmic reticulum quality control glycoprotein sensors UDP-glucose:glycoproteinglucosyltransferase (UGGT)1 and UGGT2 were identified using a glycoproteomics approach and the role for their modification was explored.

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