Evolving E. coli NfsA for enhanced chloramphenicol detoxification in the native host environment shows that eliminating substrate competition can occur rapidly, and be key to evolving a new enzymatic function.
Time-lapse imaging and the modular recreation of host physiology reveal that alveolar epithelial cells, potential permissive infection sites for Mycobacterium tuberculosis, can restrict early bacterial growth via surfactant secretion.
Applying bioorthogonal chemistry to the zebrafish/Mycobacterium marinum model of tuberculosis reveals that the virulence lipid PDIM must spread into epithelial cells in order for mycobacteria to establish infection.
The hepatic endocannabinoid/CB1R system controls the soluble leptin receptor’s expression and/or subsequent release by Trib3-induced regulation of C/EBP homologous protein levels in hepatocytes to affect leptin signaling in the liver.
Systemic hypoxia model reveals the detrimental effect of hypoxia on mitochondrial biogenesis in activated T-cells and points at a new approach for improving viral resistance in patients with respiratory diseases.
Openly available structural imaging processing pipeline for chimpanzees including registration templates and macro-anatomical parcellation shows human-like cerebral aging and medial hemispheric organization.