972 results found
  1. July 2013

    Episode 2: July 2013

    In this episode we hear about plants doing maths, the evolution of cancer, why blood vessels don'€™t grow in the retina, the immune system and more.
  2. Episode 53: January 2019

    In this episode, we hear about memory consolidation, breast cancer, leafcutter ants, deep-sea biodiversity and the beneficial effects of oxytocin on our health.
    1. Neuroscience

    Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons

    Jason D Vevea, Edwin R Chapman
    Knockoff is a tool for researchers who wish to acutely disrupt a membrane protein.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

    Ira Alexandra Iosub et al.
    High-throughput RNA-RNA interaction analysis uncovers many novel sRNA-target interactions at various growth stages in Escherichia coli.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Neuroscience

    Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

    Özgür Genç et al.
    Forward genetic screens define a novel genetic landscape by which diverse, unrelated autism risk genes may converge to commonly affect the robustness of synaptic transmission.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

    Agata Wesolowska-Andersen et al.
    Combination of deep learning models trained on tissue-specific genomic data and fine-mapping approaches supports efforts to identify causal variants and mechanisms at GWAS loci.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Chromatinization of Escherichia coli with archaeal histones

    Maria Rojec et al.
    Escherichia coli is surprisingly tolerant to chromatinization by archaeal histones, suggesting that histones can become established as ubiquitous chromatin proteins without interfering critically with some key DNA-templated processes.
    1. Evolutionary Biology

    Membranes, energetics, and evolution across the prokaryote-eukaryote divide

    Michael Lynch, Georgi K Marinov
    The common view that the mitochondrion endowed eukaryotes with a boost in bioenergetic capacity above that in prokaryotes is inconsistent with a diversity of cellular features.
    1. Developmental Biology

    Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain

    Sylvie Remaud et al.
    Production of remyelinating subventricular zone oligodendrocyte progenitors is stimulated by transient abrogation of thyroid hormone signalling in the adult neural stem cell niche.

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