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    1. Developmental Biology

    SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients

    Fei Liang et al.
    Combined evidence of human genetics, in vitro cardiomyocyte differentiation, and mouse model indicates that SORBS2 is a regulator of second heart field development and its deficiency causes seemingly opposite atrial septal defects.
    1. Computational and Systems Biology
    2. Medicine

    Heart Attack: Working together

    Regan Odongo, Tunahan Çakır
    Heart attacks have a ripple effect on how other organs exchange biomolecules that help the heart respond to injury.
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    1. Neuroscience

    Cross-species analysis defines the conservation of anatomically segregated VMH neuron populations

    Alison H Affinati et al.
    This atlas and analysis of conserved ventromedial hypothalamic nucleus (VMH) neuron populations provides an unbiased starting point for the analysis of VMH circuitry and function.
    1. Neuroscience

    Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins

    Angelo Forli et al.
    A new soma-targeted variant of the large-conductance blue-light-sensitive opsin CoChR combined with advanced optical stimulation methods allows high-efficiency all-optical neuronal imaging and stimulation in mouse brain in vivo.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation

    Elizabeth R Hughes et al.
    Bioinformatics analyses and experiments in mouse models reveal how Escherichia coli accesses the molecular hydrogen pool to boost colonization during acute colitis.
    1. Neuroscience

    Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

    Sebastian Hückesfeld et al.
    Core of a neuroendocrine synaptic network consists of a parallel set of interneurons that target distinct combinations of neuroendocrine outputs, thus enabling variability and flexibility in selection of physiological activity.
    1. Cell Biology
    2. Immunology and Inflammation

    Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

    Timurs Maculins et al.
    Multiplexed mass spectrometry shows how the autophagy gene Atg16l1 regulates macrophage innate immunity against intracellular bacterial pathogens by modulating basal oxidative stress responses.
    1. Cell Biology
    2. Immunology and Inflammation

    Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

    Nadja Kern et al.
    Manipulating nanoscale spacing of Fcγ receptors using DNA origami demonstrates that ligand clustering regulates receptor phosphorylation and phagocytosis.
    1. Neuroscience

    Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala

    Vijay K Samineni et al.
    Circuit and transcriptional analysis shows that genetically defined central amygdala neurons and their projections to the ventral periaqueductal gray mediate behavioral and affective responses to pruritus.
    1. Structural Biology and Molecular Biophysics

    The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel

    Hai Li et al.
    Substrate-induced structural changes in GtACR1 provide new insight into the chemical mechanism of natural light-gated anion conductance and facilitate its optimization for photoinhibition of neuron firing in optogenetics.