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Defective STIM-mediated store operated Ca
entry in hepatocytes leads to metabolic dysfunction in obesity
Ana Paula Arruda et al.
Store operated calcium entry is defective in hepatocytes of obese mice, and restoring this process is sufficient to improve glucose metabolism.
Dnmt3a is an epigenetic mediator of adipose insulin resistance
Dongjoo You et al.
Mouse and tissue culture studies reveal that adipose DNA methyltransferase 3a mediates insulin resistance, partially through repressing the expression of
MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice
Shilpak Bele et al.
Class 1 histone deacetylase (HDAC) inhibitor MS-275 enhances the efficacy of glucagon-like peptide 1 receptor (GLP-1R) therapy for glycemic control and reduction of obesity.
POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels
Alexandre Caron et al.
A subset of hypothalamic POMC neurons that express leptin receptors control metabolic responses to changing energy availability including regulating blood glucose and leptin levels.
Physics of Living Systems
A microfluidic device for inferring metabolic landscapes in yeast monolayer colonies
Zoran S Marinkovic et al.
Metabolic gradients underlie gene expression patterns within spatially controlled expanding 2D microbial colonies.
Insulin regulates POMC neuronal plasticity to control glucose metabolism
Garron T Dodd et al.
Feeding and fasting associated alterations in proopiomelanocortin neuronal responses to insulin coordinate glucose metabolism.
Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway
Barak Blum et al.
Loss of mature β cell identity in diabetes can be prevented and rescued by small molecule inhibitors of the TGFβ pathway.
Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells
Jonghyeob Lee et al.
Cells from the human pancreatic duct can be grown in culture and triggered to become insulin-producing cells, which could potentially be transplanted into patients with diabetes.
Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice
Yu Shi, Fanxin Long
Targeted activation of Hedgehog signalling via Gli2 facilitated the reduction of high-fat-diet-induced obesity and improvement of whole-body glucose tolerance and insulin sensitivity in adult mice.
Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis
Yu A An et al.
Gain- and loss-of-function studies highlight the important role for angiopoietin-2 to maintain adipose tissue health during metabolic challenges.
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