The combined use of NAD+ with ribitol or ribose potentiates the rescue of α-dystroglycan functional glycosylation in FKRP-mutant patient-specific iPSC-derived myotubes, representing potential novel treatments for FKRP muscular dystrophies.
Novel high-throughput co-culture assays reveal how the spatial structure of colony biofilms provides opportunities for nutrient and matrix sharing and may drive the evolution of cooperative behaviors.
Optogenetic experiments show that bridging microtubules buffer chromosome movements and promote their alignment through forces transferred to the associated kinetochore fibers, which rely on precise regulation of the overlap region.
The natural volatile component DMNT protects plants from insect attacks by damaging peritropic matrix barriers in insect midguts, paving a promising way for the molecular breeding of plant protection.
Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
Estrogen receptor alpha in the hypothalamus is required for the effects of chronic tamoxifen treament on gene expression, thermoregulation, bone, and movement in mice.
The results here show that Stu2 binds kinetochores by associating with the Ndc80 complex and that the interaction is critical for accurate chromosome segregation during cell division.
A novel type of metabolic syndrome, derived from computational modeling of phenotypic diversity in normal physiological settings, increases the risk of certain complex diseases.
