2,300 results found
    1. Neuroscience

    Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency

    Richard B Crouse et al.
    The release of acetylcholine in the basolateral amygdala is precisely timed to salient events during reward learning but has long-lasting effects that potentiate learning of cue-reward contingencies.
    1. Neuroscience

    Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex

    Andreas Hoehne et al.
    Transient recruitment of electrical synapses mediates precisely timed excitation and inhibition to enhance synchronized control of cerebellar cortical output.
    1. Neuroscience

    Vascular control of the CO2/H+-dependent drive to breathe

    Colin M Cleary et al.
    Understanding how loss of CO2/H+ vascular reactivity affects respiratory control may facilitate development of treatments for breathing problems in this population.
    1. Neuroscience

    CB1-receptor-mediated inhibitory LTD triggers presynaptic remodeling via protein synthesis and ubiquitination

    Hannah R Monday et al.
    CB1-receptor-mediated inhibitory long-term depression (LTD) relies on both protein synthesis and ubiquitination to elicit structural changes that underlie long-term reduction of GABA release.
    1. Plant Biology

    Phosphatidylcholines from Pieris brassicae eggs activate an immune response in Arabidopsis

    Elia Stahl et al.
    Plants detect the presence of phospholipids in eggs from a herbivorous insect and trigger innate immunity.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

    Kuan-Yi Lu et al.
    Phosphatidylinositol 3-phosphate interacts with PfHsp70-1 and stabilizes the Plasmodium digestive vacuole under febrile temperatures.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein

    Mikel Garcia-Marcos et al.
    LOV2GIVe allows to activate Gi proteins non-invasively with innocuous blue light based on a design principle unrelated to light-activated GPCRs (metazoan opsins), thereby expanding the range of potential experimental applications.
    1. Developmental Biology
    2. Genetics and Genomics

    MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

    Meltem Weger et al.
    The glucose-sensing transcription factor MondoA regulates zebrafish epiboly via cholesterol biosynthesis genes including the human disease gene Nsdhl, revealing an unknown role for metabolic glucose signalling in vertebrate development.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels

    Elisa Gómez-Gil et al.
    Microscopic and biochemical analysis show that the stress-activated MAP kinase pathway targets the formin For3 to modulate actomyosin ring integrity in response to environmental cues.
    1. Neuroscience

    Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment

    Aniket Ghosh et al.
    Neuronal neurofascin takes a surprisingly circuitous route in the neuronal plasma membrane to the axon initial segment where it stabilises ion channel complexes responsible for initiating action potentials.

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