529 results found
    1. Neuroscience

    Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons

    Nao Chuhma et al.
    Dopamine neurons make novel glutamatergic connections to striatal cholinergic interneurons in the lateral dorsal striatum that are mediated by metabotropic glutamate receptors coupled to TrpC channels.
    1. Neuroscience

    Dopamine neuron dependent behaviors mediated by glutamate cotransmission

    Susana Mingote et al.
    The conditional reduction of glutaminase in mouse dopamine neurons selectively attenuates glutamate cotransmission at phasic frequencies, revealing the role of dopamine neuron glutamate cotransmission in the attribution of motivational salience.
    1. Neuroscience

    Neuronal activity determines distinct gliotransmitter release from a single astrocyte

    Ana Covelo, Alfonso Araque
    A single astrocyte can decode neuronal activity and, consequently, release distinct gliotransmitters that differentially regulate neurotransmission at single hippocampal synapses.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Auxiliary subunits keep AMPA receptors compact during activation and desensitization

    Jelena Baranovic, Andrew JR Plested
    The auxiliary protein Stargazin limits the conformational dynamics of AMPA-type glutamate receptors in cell membranes, as revealed by 'molecular rulers' deployed on the seconds to milliseconds timescale.
    1. Neuroscience

    Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity

    Angela K Nietz et al.
    Climbing fiber glutamate spillover enhances response complexity and regulates signaling to Golgi cells through a form of transmission not constrained to synapses.
    1. Ecology
    2. Plant Biology

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
    1. Evolutionary Biology
    2. Neuroscience

    Glutamate Receptors: Family matters

    Mark L Mayer, Timothy Jegla
    Genome sequence data from a range of animal species are raising questions about the origins of glutamate receptors.
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    1. Cell Biology
    2. Neuroscience

    Neuropharmacology: How ketamine helps to overcome depression

    Thu N Huynh, Eric Klann
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    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert et al.
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
    1. Neuroscience

    Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons

    Shigetomo Suyama et al.
    Neurons in the hypothalamus that promote satiety manifest plasticity of their response to the excitatory transmitter, glutamate, by re-organizing the composition of a specific glutamare receptor.

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