960 results found
    1. Cell Biology
    2. Neuroscience

    Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts

    Moritz Armbruster, Mirko Messa ... Timothy A Ryan
    The recycling of transmitter vesicles at synapses shows calcium-dependent regulation that depends on the phosphorylation status of an enzyme called dynamin.
    1. Cell Biology

    Cavin-3 dictates the balance between ERK and Akt signaling

    Victor J Hernandez, Jian Weng ... Peter Michaely
    Cavin-3 is a tumor suppressor protein that inhibits Akt signaling, suppresses Warburg metabolism, promotes apoptosis, and protects against cachexia.
    1. Developmental Biology
    2. Neuroscience

    A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing

    Wei-Ming Yu, Jessica M Appler ... Lisa V Goodrich
    Genetic studies in mice identify the transcription factor MafB as a potent regulator of specific features of the synapses underlying hearing.
    1. Neuroscience

    Development of schemas revealed by prior experience and NMDA receptor knock-out

    George Dragoi, Susumu Tonegawa
    Novel spatial representations by hippocampal cellular assemblies develop on the framework of preconfigured hippocampal networks whose homeostatic synaptic reorganization is accelerated by prior experience and CA3 NMDAR-dependent plasticity.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li, Sika Zheng ... Douglas L Black
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Neuroscience

    The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles

    Lishi Li, David D Ginty
    Close examination of lanceolate mechanosensory complexes has revealed clues about the ways that sensory nerves detect the movement of hairs and shown than terminal Schwann cells are needed to maintain and regenerate these intricate structures.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling

    Ariane Briegel, Mark S Ladinsky ... Grant J Jensen
    Bacterial cytoplasmic chemoreceptors assemble into a sandwich of two hexagonally packed arrays.
    1. Neuroscience

    RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling

    Olga Ostrovskaya, Keqiang Xie ... Kirill A Martemyanov
    A critical regulator of inhibitory neurotransmitter signaling in the hippocampus has been identified in experiments on mice and been shown to play essential role in synaptic plasticity and memory.
    1. Neuroscience

    Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis

    Nicolas X Tritsch, Won-Jong Oh ... Bernardo L Sabatini
    The molecular mechanisms by which midbrain dopamine neurons acquire the inhibitory neurotransmitter GABA for synaptic release are revealed.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

    Ivana Petrovska, Elisabeth Nüske ... Simon Alberti
    A starvation-induced drop in cytosolic pH promotes assembly of budding yeast glutamine synthetase into enzymatically inactive filaments that function as enzyme storage depots.

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