919 results found
    1. Evolutionary Biology
    2. Neuroscience

    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

    David Ramos-Vicente et al.
    The animal phylogeny of glutamate receptors indicates that vertebrate types do not account for all receptor classes originated during evolution, neither are they the pinnacle of a linear evolutive process.
    1. Neuroscience

    Optocontrol of glutamate receptor activity by single side-chain photoisomerization

    Viktoria Klippenstein et al.
    Introduction of single photoswitchable unnatural amino acid into a neuronal receptor provides reversible, rapid and robust control of its activity by light, representing an important contribution to the fast expanding field of optopharmacology.
    1. Neuroscience

    Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons

    Shigetomo Suyama et al.
    Neurons in the hypothalamus that promote satiety manifest plasticity of their response to the excitatory transmitter, glutamate, by re-organizing the composition of a specific glutamare receptor.
    1. Cell Biology
    2. Neuroscience

    Filamin, a synaptic organizer in Drosophila, determines glutamate receptor composition and membrane growth

    GaYoung Lee, Thomas L Schwarz
    Filamin, by recruiting a signaling complex to the postsynapse, orchestrates the correct formation and growth of postsynaptic membranes and localization of glutamate receptor subunits.
    1. Cell Biology
    2. Neuroscience

    Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

    David Moreno Delgado et al.
    Innovative approaches were used to identify the specific pharmacological properties of heterodimeric metabotropic glutamate receptors composed of mGlu2 and mGlu4 subunits, and reveal their existence in a neuronal cell line and in perforant path terminals.
    1. Evolutionary Biology
    2. Neuroscience

    Glutamate Receptors: Family matters

    Mark L Mayer, Timothy Jegla
    Genome sequence data from a range of animal species are raising questions about the origins of glutamate receptors.
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    1. Neuroscience

    Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons

    Nao Chuhma et al.
    Dopamine neurons make novel glutamatergic connections to striatal cholinergic interneurons in the lateral dorsal striatum that are mediated by metabotropic glutamate receptors coupled to TrpC channels.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

    Irene Riva et al.
    Glutamate receptor auxiliary proteins exert their effects on receptor gating through two divergent extracellular loops, explaining subunit specificity and allowing the construction of null versions that form complexes normally but do not modify receptor gating.
    1. Developmental Biology
    2. Neuroscience

    Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival

    Eleni Kougioumtzidou et al.
    Electrically active axons in white matter stimulate their own myelination by releasing glutamate, which signals through AMPA-type glutamate receptors on nearby oligodendrocyte precursors and newly-differentiating oligodendrocytes, enhancing their survival and hence their ability to myelinate.
    1. Neuroscience

    Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease

    Jeremy F Atherton et al.
    In mouse models of Huntington's disease, the subthalamic nucleus, which suppresses movements, also exhibits impaired glutamate homeostasis, NMDA receptor-dependent mitochondrial oxidant stress, firing disruption, and 30% neuronal loss.

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