A small non-coding RNA, SNORD90, links monoaminergic directed antidepressant treatment with glutamatergic activation.

By harnessing antibody fragments conjugated to small gold nanoparticles together with high pressure freezing, FIB/SEM milling and cryo-electron tomography, AMPA receptors were identified from mouse brain tissue.

In mouse models of Rett syndrome, the impaired cell autonomous BDNF feed forward signaling pathway results in abnormalities in neurite outgrowth and synapse formation in excitatory neurons.

A combination of physiological, histological, and optical approaches reveals synapse-specific function of α-synuclein in mouse brain under both normal and pathological states.

Experiments examining the actions of morphine on single neurons from one of the brain's reward centers, the VTA, reveal the mechanism by which the drug exerts its hedonic effects.

Whole-brain quantitative input-output circuits of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei were mapped using viral tracing and high-resolution optical imaging.

Combined optogenetics and electrophysiology in vivo identified the cellular substrate of hippocampal drive that initiates the oscillatory entrainment of prefrontal cortex in neonatal mice.

Leptin acts in the paraventricular nucleus to slowly increase sympathetic nerve activity to skeletal muscle and brown adipose tissue via induction of its own receptor in TRH glutamatergic neurons.

Targeting a genetically-encoded glutamate sensor to postsynaptic sites demonstrates the feasibility of simultaneous optical quantal analysis of many inputs to a neuron in wide-field fluorescence microscopy.

AMP-activated protein kinase directly coordinates glutamatergic signalling during starvation in C. elegans.