383 results found
    1. Developmental Biology
    2. Immunology and Inflammation

    Identification of functionally distinct macrophage subpopulations in Drosophila

    Jonathon Alexis Coates et al.
    Drosophila macrophages are a heterogeneous population of cells containing subpopulations with enhanced responses to injury that display considerable variation in their abundance across development.
    1. Immunology and Inflammation

    Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages

    Carolin Ulbricht et al.
    Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.
    1. Cell Biology

    A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage

    Madhuja Samaddar et al.
    A whole-genome genetic screen links new aspects of oocyte maturation to proteostasis renewal in the immortal Caenorhabditis elegans germ-cell lineage and reveals similarities to somatic cell maintenance during aging.
    1. Developmental Biology

    In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration

    Mira I Pronobis et al.
    Proximity labeling-based proteomic strategies applied in zebrafish identify new insights into protein network changes in heart muscle cells during regeneration and implicate Rho A as a target of ErbB2 signaling during zebrafish heart regeneration.
    1. Computational and Systems Biology

    Control and regulation of acetate overflow in Escherichia coli

    Pierre Millard et al.
    Elucidating the control and regulation of acetate overflow in E. coli reveals that acetate is not only an end-product but also a co-substrate and a global regulator of glucose metabolism.
    1. Biochemistry and Chemical Biology

    HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase

    Johannes Rudolph et al.
    The polymerase activity of PARP1 is converted to hydrolase activity upon binding of Histone Parylation Factor 1 (HPF1) with nucleosome activators.
    1. Evolutionary Biology

    Group phenotypic composition in cancer

    Jean-Pascal Capp et al.
    Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
    1. Cancer Biology
    2. Cell Biology

    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

    Margaret E Torrence et al.
    ATF4 is a metabolic effector of mTORC1 signaling, co-opted to induce gene targets involved in amino acid synthesis, uptake, and tRNA charging, contributing to mTORC1-driven protein and glutathione synthesis.
    1. Immunology and Inflammation
    2. Neuroscience

    Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

    Sina C Rosenkranz et al.
    Inducing neuronal mitochondrial activity during central nervous system inflammation counteracts inflammation-induced neuronal electron transport chain deficiency and calcium toxicity, thereby protecting against neuronal loss in a multiple sclerosis mouse model.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

    Wiebke Nahrendorf et al.
    Malaria remodels the spleen to imprint tolerance and reduce pathology in subsequent infections.

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