825 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

    Huan Yan, Guocai Zhong ... Wenhui Li
    Biochemical and genetic tests have revealed that a liver protein called NTCP is a functional receptor for hepatitis B and D viruses, which should lead to an improved understanding of the infections caused by these viruses and assist the development of new intervention strategies.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates

    Tijana Ivanovic, Jason L Choi ... Stephen C Harrison
    Long-lived intermediate states formed by glycoprotein catalysts are an essential part of the process used by influenza virus particles to infect cells.
    1. Neuroscience

    Convergence of pontine and proprioceptive streams onto multimodal cerebellar granule cells

    Cheng-Chiu Huang, Ken Sugino ... Adam W Hantman
    Individual granule cells within the cerebellum-the region of the brain that coordinates movement and supports the learning of new motor skills-receive both sensory and motor input streams: an arrangement that may help the brain to use feedback to fine-tune movement.
    1. Structural Biology and Molecular Biophysics

    Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

    Siyang Sun, Ye Xiang ... Michael G Rossmann
    Electron cryo-microscopy has been used to determine the structure of Chikungunya virus-like particles and to provide new insights into their interactions with four different antibodies.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

    Joshua T Schiffer, David Swan ... Lawrence Corey
    A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.
    1. Cell Biology

    TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells

    Sandra Mitrovic, Cristina Nogueira ... Vivek Malhotra
    Goblet cells secrete mucins—which are key components of mucus—in a process that is regulated by calcium ions, which enter the goblet cells via a mechanism involving a channel protein called TRPM5.
    1. Cell Biology

    Intraflagellar transport drives flagellar surface motility

    Sheng Min Shih, Benjamin D Engel ... Ahmet Yildiz
    The transport of proteins along flagellar microtubules generates the force that enables flagella to propel cells across surfaces.
    1. Cell Biology

    Cell Biology: Hopping rim to rim through the Golgi

    Suzanne R Pfeffer
    Version of Record
    Insight
    1. Developmental Biology
    2. Genetics and Genomics

    The genome sequence of the colonial chordate, Botryllus schlosseri

    Ayelet Voskoboynik, Norma F Neff ... Stephen R Quake
    The Botryllus schlosseri genome yields insights into the evolution of hematopoiesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

    Mari Nishino, Jonathan W Choy ... Jack Taunton
    Hypothemycin, which inhibits a number of protein kinases, kills the T. brucei parasites that cause sleeping sickness and reveals new therapeutic targets for the disorder.

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