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    1. Cell Biology

    Centrosome Migration and Apical Membrane Formation in Polarized Epithelial Cells: Insights from the MDCK Cyst Model

    Po-Kai Wang, Keng-Hui Lin, Tang K Tang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

    Jayati Gera, Marishia Agard ... Meet Zandawala
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

    Stephen A Banse, Christine A Sedore ... Patrick C Phillips
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology

    An atypical basement membrane forms a midline barrier during left-right asymmetric gut development in the chicken embryo

    Cora Demler, John Coates Lawlor ... Natasza A Kurpios
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    • Convincing
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions

    Luka Jarc, Manuj Bandral ... Anthony Gavalas
    The signaling requirements to decouple proliferation of pancreatic progenitors from differentiation were elucidated and employed for the reproducible expansion, under GMP-compliant conditions, of pancreatic progenitors derived from different human pluripotent stem cell lines.
    1. Cell Biology

    A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

    David B Heisler, Kristen A Johnson ... Arun Radhakrishnan
    An essential role for ACAT in conferring 25HC-mediated protection against bacterial and viral infection has been uncovered.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Hematopoietic plasticity mapped in Drosophila and other insects

    Dan Hultmark, István Andó
    A critical analysis of recent single-cell transcriptomic studies of Drosophila blood cells confirms the extreme plasticity of the major phagocyte class, identifies a new class of blood cell, and suggests relationships to blood cells in other insects.
    1. Developmental Biology

    Reorganization of the flagellum scaffolding induces a sperm standstill during fertilization

    Martina Jabloñski, Guillermina M Luque ... Mariano G Buffone
    The double helix actin network surrounding the mitochondrial sheath of the sperm midpiece undergoes structural changes prior to the motility cessation during sperm-egg fusion.
    1. Cell Biology

    Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS–Hook–FHIP complexes

    Jenna R Christensen, Agnieszka A Kendrick ... Samara L Reck-Peterson
    The combinatorial assembly of different adaptor complexes is a mechanism that dynein uses to interact with multiple cargos.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody

    Angela M Phillips, Daniel P Maurer ... Michael M Desai
    An anti-influenza receptor binding site antibody acquires breadth through hierarchical sets of epistatic mutations distributed across the light and heavy chains, demonstrating how mutations can interact to shape the evolution of antibody breadth in various antigen exposure regimens.
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