Roundworms and yeast can survive extreme desiccation only by switching their metabolism into a gluconeogenic mode and producing very high amounts of trehalose via the glyoxylate shunt.

Multi-omics reveals that Alkb homolog 7 (ALKBH7), α mitochondrial alpha-ketoglutarate dioxygenase of unclear function, regulates glyoxal metabolism, which may explain its role in necrosis and heart attack.

Advanced glycation end-products (compounds which make the food appetizing and aromatic) intricately modulate organism’s homeostatic and hedonistic signaling pathways thereby inducing preferential consumption of excess nutrients offering preliminary insights into overconsumption of modern-day processed food.

Yeast DJ-1 homologs are molecular erasers of glycation adducts on cellular macromolecules and preserve mitochondrial health through redistributing into mitochondria under elevated carbonyl stress.

daf-16/FoxO restructures metabolism during acute starvation to promote synthesis of trehalose, which supports survival as a stress protectant and energy source.

Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens.

Carbonyl stress mediated by Methylglyoxal affects Hsp90 activity, inhibits the Hippo pathway and promotes tumor growth and metastasis in breast cancer.

Biochemical and genome-wide analysis demonstrates that m¹G37 is important for tRNA aminoacylation and for the entire elongation cycle of protein synthesis.

Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.

The stability of metabolic autocatalytic cycles that are widespread in central metabolism limits the affinities of enzymes at flux branch points and explains excess expression of these enzymes.