978 results found
    1. Neuroscience

    Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry

    Xenia Grande, Magdalena M Sauvage ... David Berron
    The human entorhinal-hippocampal circuitry is characterized by an information-specific functional organization where two routes, that are preferentially connected to the parahippocampal cortex or the perirhinal and retrosplenial cortices, divide the entorhinal cortex as well as hippocampal subiculum and CA1 subregions.
    1. Neuroscience

    Stimulus-dependent relationships between behavioral choice and sensory neural responses

    Daniel Chicharro, Stefano Panzeri, Ralf M Haefner
    New stimulus-dependencies of choice-related signals in sensory neurons uncovered by new analytical results and methods.
    1. Structural Biology and Molecular Biophysics

    Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions

    Connor J Thompson, Zhaoqian Su ... Daniel K Schwartz
    A combined experimental and computational approach was developed to understand lateral interactions between membrane-bound proteins and used to quantify the contributions of specific and non-specific interactions to cadherin cis-binding kinetics.
    1. Cell Biology
    2. Computational and Systems Biology

    Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics

    Saskia MA de Man, Gooitzen Zwanenburg ... Renée van Amerongen
    Genome editing, advanced live-cell microscopy, and computational modeling were combined to measure WNT/CTNNB1 signaling parameters at the single molecule level, revealing critical regulatory nodes in this important signal transduction pathway.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Oomycete small RNAs bind to the plant RNA-induced silencing complex for virulence

    Florian Dunker, Adriana Trutzenberg ... Arne Weiberg
    Small RNAs of distantly related plant pathogens, such as fungi and oomycetes, hijack the plant RNA-induced silencing complex to favor host infection.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The emergence and evolution of gene expression in genome regions replete with regulatory motifs

    Timothy Fuqua, Yiqiao Sun, Andreas Wagner
    Mutagenizing sequences enriched with promoter motifs creates gene expression de novo, and helps to understand promoter logic, regulatory evolution, and the birth of de novo genes.
    1. Neuroscience

    Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells

    Yuwei Cui, Yanbin V Wang ... Daniel A Butts
    The convergence of two visual pathways at the level of retinal bipolar cells accounts for key features of ganglion cell responses.
    1. Neuroscience

    Tracking prototype and exemplar representations in the brain across learning

    Caitlin R Bowman, Takako Iwashita, Dagmar Zeithamova
    Concepts can be represented at multiple levels of specificity (individual examples, abstract category averages) within a single task across different regions of the brain.
    1. Neuroscience

    Slowing the body slows down time perception

    Rose De Kock, Weiwei Zhou ... Martin Wiener
    The perception of time is influenced by movement environments, with slower movements associated with shorter perceived time intervals.
    1. Computational and Systems Biology
    2. Neuroscience

    Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex

    Atle E Rimehaug, Alexander J Stasik ... Anton Arkhipov
    A biophysically detailed model of mouse primary visual cortex reproduces, in a quantitative manner, experimentally recorded spikes and local field potentials, and suggests mechanisms that form current sinks and sources in vivo.

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