999 results found
    1. Neuroscience

    A neuronal least-action principle for real-time learning in cortical circuits

    Walter Senn, Dominik Dold ... Mihai A Petrovici
    A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.
    1. Microbiology and Infectious Disease

    Small RNAs from mitochondrial genome recombination sites are incorporated into T. gondii mitoribosomes

    Sabrina Tetzlaff, Arne Hillebrand ... Christian Schmitz-Linneweber
    Sequences at mitochondrial genome recombination sites are dually used as mRNAs and as rRNAs in actively translating mitoribosomes of T. gondii.
    1. Cell Biology

    Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes

    Aidan M Fenix, Abigail C Neininger ... Dylan T Burnette
    Sarcomeres in heart muscle cells come from stress fiber-like structures that are mechanistically distinct from stress fibers in non-muscle cells.
    1. Biochemistry and Chemical Biology

    Talin-activated vinculin interacts with branched actin networks to initiate bundles

    Rajaa Boujemaa-Paterski, Bruno Martins ... Ohad Medalia
    At adhesion sites, talin-activated vinculin promotes interactions with the actin network that initiates bundles.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

    Pim J Huis in 't Veld, Vladimir A Volkov ... Marileen Dogterom
    Binding of two macromolecular complexes allows kinetochores to capture force produced by the depolymerising ends of microtubules, allowing chromosomes to be transmitted from a mother cell to its two daughters.
    1. Developmental Biology
    2. Neuroscience

    Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions

    Miguel Ramirez, Yuliya Badayeva ... Daniel Goldowitz
    An analysis of enhancer activity during mouse cerebellar development provides an invaluable resource for studying gene expression regulation by enhancers in the developing cerebellum and delivers a rich dataset of novel gene-enhancer associations providing a basis for future in-depth studies.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Population scale mapping of transposable element diversity reveals links to gene regulation and epigenomic variation

    Tim Stuart, Steven R Eichten ... Ryan Lister
    Fine mapping of transposable element presence/absence variation amongst 216 Arabidopsis strains uncovers widespread novel genetic diversity that underlies differences in transcription and DNA methylation patterns.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

    Pierre Khoueiry, Charles Girardot ... Eileen EM Furlong
    Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
    1. Cancer Biology

    Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence

    Janusz Franco-Barraza, Ralph Francescone ... Edna Cukierman
    Stromal cell levels and localization of active α5β1-integrin are regulated by desmoplastic extracellular matrix control of αvβ5-integrin signaling, and predict clinical outcomes for pancreatic and renal cancer patients.
    1. Cell Biology

    Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised

    Sara Sannino, Megan E Yates ... Jeffrey L Brodsky
    Unique integrate stress response sensors differentially trigger pro-survival versus pro-apoptotic responses in cells confronted with Hsp70 inhibitor-associated proteotoxic challenges.

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