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    1. Cell Biology

    Distinct trafficking routes of polarized and non-polarized membrane cargoes in Aspergillus nidulans

    Georgia Maria Sagia, Xenia Georgiou ... Sofia Dimou
    Unconventional secretion of a plasma membrane purine transporter via Golgi-bypass is established at an early ER-associated secretory compartment revealing that specific cargoes define alternative trafficking routes.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Systematic evaluation of multifactorial causal associations for Alzheimer’s disease and an interactive platform MRAD developed based on Mendelian randomization analysis

    Tianyu Zhao, Hui Li ... Li Chen
    A new online data analysis platform, Mendelian Randomization for Alzheimer’s Disease (MRAD), enables the identification of risk or protective factors for Alzheimer’s disease.
    1. Microbiology and Infectious Disease

    Inhibitors of the small membrane (M) protein viroporin prevent Zika virus infection

    Emma Brown, Gemma Swinscoe ... Stephen Griffin
    A new way to treat Zika virus infections could be achieved following the definition of an ion channel function for the M protein within virus particles.
    1. Neuroscience

    DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

    Ernie Yulyaningsih, Jung H Suh ... Pascal E Sanchez
    DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.
    1. Cell Biology
    2. Immunology and Inflammation

    S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

    Daniel M Williams, Andrew A Peden
    Recruitment of NLRP3 to the Golgi is controlled by the reversible addition of a lipid anchor adjacent to the polybasic region.
    1. Cancer Biology

    Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

    Elazar Besser, Anat Gelfand ... David Meiri
    The cannabinoids cannabidiol, cannabidivarin, and the newly identified 331-18A demonstrate antitumoral effects in Notch1-mutated leukemia, underscoring the potential and complexity of Cannabis as a novel treatment for cancer.
    1. Cell Biology

    Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

    Roberto Notario Manzano, Thibault Chaze ... Christel Brou
    Proteomic analysis of tunneling nanotubes (TNTs) identifies CD9 and CD81 as major positive regulators of TNT formation.
    1. Genetics and Genomics
    2. Neuroscience

    Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

    Tom Bonnifet, Sandra Sinnassamy ... Julia Fuchs
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus

    Noémie Reveyaz, Undine Schneeweiß ... Michael Brecht
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Evolutionary Biology

    Biocalcification in porcelaneous foraminifera

    Zofia Dubicka, Jarosław Tyszka ... Ulf Bickmeyer
    Porcelaneous foraminifera, marine calcifiers, reveal their biomineralization secrets.
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