Normalizing Tcf4 expression during early postnatal development improves behavioral outcomes in Pitt-Hopkins syndrome (PTHS) model mice, suggesting that genetic therapies are feasible in individuals with PTHS.
A new online data analysis platform, Mendelian Randomization for Alzheimer’s Disease (MRAD), enables the identification of risk or protective factors for Alzheimer’s disease.
André M Lazar, Roshanak Irannejad ... Mark Von Zastrow
An adenylyl cyclase isoform is shown to dynamically traffic to endosomes after activation by G protein in mammalian cells, contributing to cellular cAMP signaling by internalized GPCRs.
The Spike gene expressed by the vector-based vaccine Vaxzevria bears the risk of cryptic splicing, which in turn may lead to cellular production of soluble, instead of membrane-anchored, Spike protein variants.
Richard Burkett Dewell, Ying Zhu ... Fabrizio Gabbiani
The processing of light and dark contrast information for detecting impending visual threats within grasshopper neurons reveals new mechanisms of information processing in the brain.
Interrogating mouse locus coeruleus via large-scale multipatch whole-cell recordings uncovers its cellular heterogeneity and cell-type-specific wiring logic.
Patch-clamp electrophysiology, fluorescence imaging, and computational modeling were used to identify cellular mechanisms underlying maturation of dendritic computations in interneurons.
