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    1. Immunology and Inflammation

    EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

    Lyra O Randzavola, Paige M Mortimer ... David C Thomas
    Biochemical and cellular analyses reveal the mechanism by which EROS regulates NOX2 and P2X7 abundance in mouse and human.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

    George Ueda, Aleksandar Antanasijevic ... David Baker
    De novo protein nanoparticles were designed from scratch to present viral glycoprotein antigens, providing a systematic way to study the influence of antigen presentation geometry on immune response.
    1. Structural Biology and Molecular Biophysics

    Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

    Subu Subramanian, Kent Gorday ... John Kuriyan
    Deep mutagenesis of a clamp-loader complex reveals a critical hydrogen-bonded junction that is important for allosteric communication in oligomeric AAA+ ATPases.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic Archaea

    Tom Killelea, Adeline Palud ... Ghislaine Henneke
    An investigation into 8-oxodeoxguanosine bypass by archaeal DNA polymerases.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages

    Jay Lubow, Maria C Virgilio ... Kathleen L Collins
    Interactions between HIV-1 Env and human mannose receptor enhance HIV entry but restrict viral egress and spread in the absence of Vpr.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

    Mark S Ladinsky, Priyanthi NP Gnanapragasam ... Pamela J Bjorkman
    Visualization of HIV-1 fusion by trapping the prehairpin intermediate.
    1. Immunology and Inflammation

    Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection

    Marco Künzli, Peter Reuther ... Carolyn G King
    T cell receptor signal strength correlates positively with Th1 generation during acute infection but negatively during chronic infection.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome-wide mapping of native co-localized G4s and R-loops in living cells

    Ting Liu, Xing Shen ... Zhihong Xue
    The newly developed antibody-free techniques, HepG4-seq for G-quadruplexes and HBD-seq for R-loops, robustly reveal the comprehensive maps of native G-quadruplexes and R-loops, as well as their roles in transcriptional regulation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide

    Erik Lee Snapp, Nicholas McCaul ... Ineke Braakman
    Signal-peptide cleavage of HIV-1 envelope glycoprotein is delayed because of alpha-helical structure covering the cleavage site, effecting early cleavage alters the folding pathway and resulting in localized misfolding and reduced viral fitness.
    1. Cell Biology
    2. Neuroscience

    HIF1α stabilization in hypoxia is not oxidant-initiated

    Amit Kumar, Manisha Vaish ... Rajiv R Ratan
    The current findings address the redox regulation of hypoxia inducible factor 1α (HIF1α) stability in hypoxia by showing that cytosolic, mitochondrial or lipid ROS are not necessary for HIF1α stabilization in hypoxia.
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