The first global analysis of the effects of the transcription factor p53 on RNA synthesis illuminates several novels aspects of the molecular mechanism of action of this potent tumor suppressor.

Cell type-specific transcriptomics in energy homeostasis neurons has identified hundreds of genes and multiple signaling pathways that are regulated by weight loss in mice, as well as several previously unexamined genes that can regulate appetite and body weight.

Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.

Three-dimensional chromatin architecture facilitates a promoter switch in order to ensure maintained expression of a gene involved in growth during embryonic stem cell differentiation.

In the brain of medaka fish, neuropeptide B acts directly downstream of estrogen in a female-specific but reversible manner to mediate female receptivity to male courtship.

Bile acid and it's receptor MRGPRX4, but not TGR5, is one of the ligand-receptor pairs for chronic itch in patients with liver diseases.

Rare, evolutionarily recent variants have larger effect sizes and are more likely to decrease fitness, providing evidence that quantitative traits in yeast have evolved under purifying selection.

GPR88 inhibits G-protein signaling of nearby GPCRs, and dampens b-arrestin recruitment by all GPCRs tested, likely by sequestration in intracellular compartments.

The thioredoxin-1 (Trx1) system promotes inflammation by positively regulating both NLRP3 inflammasome responses, by detoxifying excessive ROS independently of Txnip and NF-κB binding to target DNA.

Variation in migration can evolve rapidly and traits that comprise this behaviour may be determined by standing variation at a few regulatory regions that are not common across taxonomic groups.