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Page 2 of 295
    1. Cell Biology
    2. Developmental Biology

    Dual functions of TAF7L in adipocyte differentiation

    Haiying Zhou et al.
    A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.
    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak et al.
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
  1. Living Science: Crossing oceans

    Eve Marder
    Eve Marder explains why all scientists should spend time living and working in a foreign country.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates

    Tijana Ivanovic et al.
    Long-lived intermediate states formed by glycoprotein catalysts are an essential part of the process used by influenza virus particles to infect cells.
    1. Structural Biology and Molecular Biophysics

    De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy

    Deryck J Mills et al.
    The structure of a large hydrogenase complex involved in the production of methane by microbes has been determined with cryo-electron microscopy.
    1. Neuroscience

    Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans

    Jing Yan et al.
    A cellular motor protein helps to ensure that microtubules are oriented correctly within neuronal dendrites
  2. Point of View: The writing on the wall

    Henry R Bourne
    The biomedical research enterprise in the US has become unsustainable and urgent action is needed to address a variety of problems.
    1. Structural Biology and Molecular Biophysics

    Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

    Siyang Sun et al.
    Electron cryo-microscopy has been used to determine the structure of Chikungunya virus-like particles and to provide new insights into their interactions with four different antibodies.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

    Xiao-Wei Chen et al.
    COPII vesicles regulate the metabolism of cholesterol through the selective transport of secretory proteins.
    1. Cancer Biology

    Overcoming mutation-based resistance to antiandrogens with rational drug design

    Minna D Balbas et al.
    Mutagenesis studies identified an androgen receptor mutation that converts enzalutamide-a drug recently approved for the treatment of advanced prostate cancer-into an androgen receptor agonist, and modeling studies informed the design of novel drugs that are effective against the mutant receptor.