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    1. Neuroscience

    Mapping brain-behavior space relationships along the psychosis spectrum

    Jie Lisa Ji et al.
    A data-reduced neuro-behavioral geometry in psychosis spectrum disorders mapped symptoms stably on to distinct functional brain regions and offers a framework for informing personalized treatment selection decisions.
    1. Chromosomes and Gene Expression

    DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

    Pedro Ortega et al.
    Genetic and physical analyses reveal that DNA-RNA hybrids form fortuitously at DNA double-strand breaks during transcription and need removal to allow repair by homologous recombination.
    1. Cell Biology
    2. Developmental Biology

    Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

    Melissa T Adams et al.
    Synchronized β cell response to glucose is lost concomitant with loss of islet architecture in Robo-deficient islets of Langerhans in vivo.
    1. Microbiology and Infectious Disease

    Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates

    Megan Culler Freeman et al.
    Parallel studies in primary human airway cells and stem cell-derived enteroids show that Enterovirus D-68 differentially infects and induces innate immune signaling in the respiratory and intestinal epithelium.
    1. Evolutionary Biology

    Contingency and chance erase necessity in the experimental evolution of ancestral proteins

    Victoria Cochran Xie et al.
    Replicating experimental evolution from ancestral proteins shows that historical contingency steadily overwhelms chance and necessity as the primary cause of evolutionary variation in molecular sequences on long phylogenetic timescales.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Crash landing of Vibrio cholerae by MSHA pili-assisted braking and anchoring in a viscoelastic environment

    Wenchao Zhang et al.
    Mannose-sensitive hemagglutinin pili act as a braking and anchoring machine during the three-phase landing process of Vibrio cholerae.
    1. Genetics and Genomics

    Psychosocial experiences modulate asthma-associated genes through gene-environment interactions

    Justyna A Resztak et al.
    Psychosocial environments modulate genetic risk of asthma and other allergic diseases through altered peripheral blood gene expression.
    1. Cell Biology
    2. Neuroscience

    Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development

    Maryam Izadi et al.
    Extended biochemical and functional analyses in primary neurons show that early neuronal morphogenesis critically relies on cooperation of the actin nucleator Cobl and its ancestor Cobl-like and uncover their cooperative mechanisms at dendritic branch initiation sites.
    1. Cancer Biology
    2. Cell Biology

    Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

    Kerrie-Ann McMahon et al.
    Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Folding of cohesin’s coiled coil is important for Scc2/4-induced association with chromosomes

    Naomi J Petela et al.
    First evidence of cohesin folding occurring in vivo and during cohesion together with a detailed description of the structural aspects of cohesin's elbow folding through a series of novel structures.