The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
Opposing gradients of Fat and Dachsous phosphorylation are sufficient to explain the observed pattern of Fat-Dachsous planar polarisation across the Drosophila wing.
Embryo-wide quantitative analysis of BMP signaling in zebrafish embryos, combined with a mathematical model-based computational screen, challenges the prevailing model of an antagonist counter-gradient shaping the gastrula BMP morphogen gradient and supports an antagonist sink with BMP diffusion mechanism.
Diffusivity, extracellular interactions of Nodal ligands with the receptors and inhibitors, and selective ligand destruction collectively shape the Nodal morphogen gradient.
A kinetic model of morphogen interpretation is more suitable than classic threshold or ratchet models to understand how a signal gradient generates different target gene expression patterns.
Shootin1a, through its spatially regulated phosphorylation within growth cones, mediates the gradient reading and mechanoresponse for netrin-1-induced axon guidance.
Advanced microscopy techniques reveal that clusters of Pom1 kinase at the membrane represent the functional unit that shape the concentration gradients and modulate Pom1 mid-cell levels according to cell size.
A minimal cell-like system with defined geometry has been used to investigate the establishment and spatial control of a protein gradient that positions the bacterial cell division machinery.
Cerebellar functional regions follow a gradual organization, which progresses from primary (motor) to transmodal (Default Mode Network) regions, and a secondary axis extends from task-unfocused to task-focused processing.
