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Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin
Toru Hiratsuka et al.
In vivo imaging of extracellular signal-regulated kinase activity reveals radial ERK activation patterns that are associated with cell cycle progression in the mouse epidermis.
Research Culture: Actionable recommendations from trainees to improve science training
Stephanie M Davis et al.
Early-career researchers propose seven actions that can be taken by research institutions and departments to improve science training.
Point of View: The writing on the wall
Henry R Bourne
The biomedical research enterprise in the US has become unsustainable and urgent action is needed to address a variety of problems.
Cutting Edge: Using mobile sequencers in an academic classroom
Sophie Zaaijer et al.
A university genomics class provides detailed examples of how to design and execute Oxford Nanopore MinION hackathons as part of an academic curriculum.
Microbiology and Infectious Disease
Research Culture: Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts
Gary S McDowell et al.
Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.
Research Culture: Career choices of underrepresented and female postdocs in the biomedical sciences
W Marcus Lambert et al.
Mentorship, financial security and a positive sense of self-worth increase the likelihood that underrepresented minority and female postdocs will pursue a career in academia.
Genetics and Genomics
Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence
Diane Marie Keeling et al.
A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
Research Culture: A survey-based analysis of the academic job market
Jason D Fernandes et al.
A survey of over 300 applicants for faculty positions reveals that there are many paths to securing a job offer.
Immunology and Inflammation
Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion
Marie Marotel et al.
Similar to T cell exhaustion, natural killer cell dysfunction in chronic hepatitis B patients results from deregulated calcium pathway.
Pregnancy-associated plasma protein-aa regulates endoplasmic reticulum–mitochondria associations
Mroj Alassaf, Mary C Halloran
An extracellular modulator of IGF1 signaling, Pappaa, regulates endoplasmic reticulum–mitochondria connections, which are critical for metabolic homeostasis and hair cell survival.
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