88 results found
    1. Microbiology and Infectious Disease

    Insect endosymbiont proliferation is limited by lipid availability

    Jeremy K Herren, Juan C Paredes ... Bruno Lemaitre
    The endosymbiont Spiroplasma can only proliferate if it can acquire sufficient hemolymph lipids from its insect host.
    1. Developmental Biology
    2. Neuroscience

    Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production

    Hector Sandoval, Chi-Kuang Yao ... Hugo J Bellen
    The dual role of Drosophila Mitofusin in steroid hormone production and cholesterol ester storage, which is evolutionary conserved by the combined expression of the two mammalian Mitofusins, ensures proper synaptic development.
    1. Neuroscience

    Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae

    Wei Zhang, Zhiqiang Yan ... Yuh Nung Jan
    The neural circuit underlying defecation behavior in Drosophila larvae has been identified and characterized.
    1. Neuroscience

    The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion

    Peter Soba, Chun Han ... Yuh Nung Jan
    A cell surface receptor called Ret enables neurons to establish and maintain the organized arrays of dendrites that support communication between neurons.
    1. Neuroscience

    Reverse-correlation analysis of navigation dynamics in Drosophila larva using optogenetics

    Luis Hernandez-Nunez, Jonas Belina ... Aravinthan DT Samuel
    Optogenetic stimulation of odor- and taste-sensing neurons of the fruit fly larva combined with reverse-correlation analysis has been used to build mathematical models that predict navigational behavior.
    1. Immunology and Inflammation

    Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

    Ran You, Wen Lu ... Farrah Kheradmand
    The accumulation of carbon black nanoparticles in smokers' lungs causes sterile inflammation, double-strand DNA breaks and emphysema.
    1. Developmental Biology

    Multipotent versus differentiated cell fate selection in the developing Drosophila airways

    Ryo Matsuda, Chie Hosono ... Kaoru Saigo
    A genetic framework that balances the numbers of multipotent precursors and differentiated cells in the developing airways of Drosophila is presented.
    1. Neuroscience

    Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila

    Qingqing Liu, Xing Yang ... Aike Guo
    Gap junctions exist in Kenyon cells and Kenyon cell-mushroom body output neuron neural networks, and are also critical in visual learning and memory in Drosophila.
    1. Neuroscience

    Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration

    Kuchuan Chen, Guang Lin ... Hugo J Bellen
    In Drosophila, the loss of Frataxin causes iron accumulation in the nervous system, which in turn enhances sphingolipid synthesis and activation of PDK1 and Mef2, which leads to neurodegeneration.
    1. Cell Biology
    2. Genetics and Genomics

    A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

    Maulik R Patel, Ganesh K Miriyala ... Harmit S Malik
    A 'male-harming' mtDNA mutation has been identified in Drosophila and impairs male fertility without impairing other male or female functions.

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