The dual role of Drosophila Mitofusin in steroid hormone production and cholesterol ester storage, which is evolutionary conserved by the combined expression of the two mammalian Mitofusins, ensures proper synaptic development.
A cell surface receptor called Ret enables neurons to establish and maintain the organized arrays of dendrites that support communication between neurons.
Luis Hernandez-Nunez, Jonas Belina ... Aravinthan DT Samuel
Optogenetic stimulation of odor- and taste-sensing neurons of the fruit fly larva combined with reverse-correlation analysis has been used to build mathematical models that predict navigational behavior.
Gap junctions exist in Kenyon cells and Kenyon cell-mushroom body output neuron neural networks, and are also critical in visual learning and memory in Drosophila.
In Drosophila, the loss of Frataxin causes iron accumulation in the nervous system, which in turn enhances sphingolipid synthesis and activation of PDK1 and Mef2, which leads to neurodegeneration.