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    1. Plant Biology

    Plant–necrotroph co-transcriptome networks illuminate a metabolic battlefield

    Wei Zhang, Jason A Corwin ... Daniel J Kliebenstein
    Simultaneously measuring the transcriptomes of both a host plant and fungal pathogen, co-transcriptomics, identified diverse, dynamic and independent communication mechanisms conveying information between the two organisms via discrete gene modules.
    1. Cell Biology
    2. Genetics and Genomics

    A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

    Maulik R Patel, Ganesh K Miriyala ... Harmit S Malik
    A 'male-harming' mtDNA mutation has been identified in Drosophila and impairs male fertility without impairing other male or female functions.
    1. Developmental Biology
    2. Neuroscience

    Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body

    Najia A Elkahlah, Jackson A Rogow ... E Josephine Clowney
    Sensory innervation density in the insect associative learning center is set by postsynaptic cells and accomplished by flexible allocation of processes by presynaptic cells.
    1. Neuroscience

    A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

    Jhan-Jie Peng, Shih-Han Lin ... Chi-Kuang Yao
    Glutamate excitotoxicity induces a circuit-dependent ROS feedback loop to alter motor system integrity.
    1. Cancer Biology

    Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila

    Hiroshi Nishida, Morihiro Okada ... Sa Kan Yoo
    Src, an oncogene, promotes both cell proliferation and cell death simultaneously, which can be regulated by dietary methionine.
    1. Developmental Biology
    2. Computational and Systems Biology

    Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the Drosophila embryo

    Hadel Al Asafen, Natalie M Clark ... Gregory T Reeves
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    Medial orbitofrontal inactivation does not affect economic choice

    Matthew PH Gardner, Jessica C Conroy ... Geoffrey Schoenbaum
    Inactivation of the medial orbitofrontal cortex using an optogenetic approach did not affect behavior in rats on an iconic economic choice task.
    1. Genetics and Genomics

    Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity

    Katja Birker, Shuchao Ge ... Rolf Bodmer
    Genes of the MICOS complex are a major candidate pathway to be potentially linked to defects in cardiomyocyte growth and differentiation in Hypoplastic left heart syndrome (HLHS), and relevant for elucidating the polygenic nature of HLHS and other CHDs.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Yerba mate (Ilex paraguariensis) genome provides new insights into convergent evolution of caffeine biosynthesis

    Federico A Vignale, Andrea Hernandez Garcia ... Adrian G Turjanski
    DNA sequencing of the yerba mate (Ilex paraguariensis) genome reveals convergent genomic changes, biochemical pathways, mutations, and substrate-binding orientations responsible for caffeine biosynthesis when compared to coffee and tea plants.
    1. Neuroscience

    Reverse-correlation analysis of navigation dynamics in Drosophila larva using optogenetics

    Luis Hernandez-Nunez, Jonas Belina ... Aravinthan DT Samuel
    Optogenetic stimulation of odor- and taste-sensing neurons of the fruit fly larva combined with reverse-correlation analysis has been used to build mathematical models that predict navigational behavior.