1,540 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Discovering and deciphering relationships across disparate data modalities

    Joshua T Vogelstein et al.
    Multiscale Graph Correlation, an interpretable hypothesis test with strong theoretical guarantees for discerning relationships in complex data, requires about half the sample size as other methods, whilst maintaining computational tractability.
    1. Evolutionary Biology

    Topological constraints in early multicellularity favor reproductive division of labor

    David Yanni et al.
    Mathematical modeling shows that reproductive specialization is strongly favored in sparse networks of cellular interactions that reflect the morphology of early multicellular organisms, even when benefits of specialization are saturating.
    1. Neuroscience

    Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

    Eric Kenji Lee et al.
    WaveMAP is a novel approach that combines nonlinear dimensionality reduction with graph clustering on extracellular waveforms to reveal previously obscured cell type diversity in monkey cortex.
    1. Computational and Systems Biology
    2. Neuroscience

    A connectome and analysis of the adult Drosophila central brain

    Louis K Scheffer et al.
    New reconstruction methods are used to create a publicly available dense reconstruction of the neurons and chemical synapses of central brain of Drosophila, with analysis of its graph properties.
    1. Neuroscience

    The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment

    Shaun S Sanders et al.
    ZDHHC14 controls palmitoylation and axon initial segment targeting of PSD93 and Kv1-family potassium channels, events that are essential for normal neuronal excitability.
    1. Computational and Systems Biology
    2. Neuroscience

    The head direction circuit of two insect species

    Ioannis Pisokas et al.
    Two evolutionary distant insect species share a common head direction circuit with subtle differences in neuronal morphologies that result in distinct circuit dynamics adapted to each species’ ecology.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Bacterial survival in microscopic surface wetness

    Maor Grinberg et al.
    A new intricate reciprocity between microbiology and physics results in collective protection from desiccation through differential formation of stable microdroplets around bacterial aggregates on surfaces drying under moderate humidity.
    1. Computational and Systems Biology
    2. Neuroscience

    Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit

    Marianne J Bezaire et al.
    Spontaneous theta oscillations and interneuron-specific phase preferences emerge spontaneously in a full-scale model of the isolated hippocampal CA1 subfield, corroborating and extending recent experimental findings.
    1. Neuroscience

    Synaptic plasticity through activation of GluA3-containing AMPA-receptors

    Maria C Renner et al.
    A novel form of hippocampal synaptic plasticity is expressed by a change in channel function of GluA3-containing AMPA-receptors.
    1. Neuroscience

    Brain states govern the spatio-temporal dynamics of resting-state functional connectivity

    Felipe Aedo-Jury et al.
    Distinct brain states govern resting state functional architecture revealed by neurophysiologically defined simultaneous optic-fiber-based calcium recordings and task-free functional magnetic resonance imaging (fMRI) in rats.

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