The neural representation of position in the medial entorhinal cortex may be stabilized by synaptic connectivity across modules, which enforces coherent updates in their states.
Dementia-related tau pathology reduces speed encoding in the medial entorhinal cortex and is associated with reduced grid cell function, whilst head direction tuning remains intact.
When a familiar environment is reshaped, the grid cell spatial code is dynamically anchored to recently encountered boundaries and changes throughout exploration with the specific movement history of the navigator.
A mouse virtual reality system is presented which allows normal spatial behavior and place, grid and head-direction cell firing patterns in 2-D arenas, and is compatible with electrophysiology and multi-photon imaging.
A computational model for the formation of neural networks of grid cells in virtual bats suggests that the highly ordered networks presumed to support spatial navigation in two dimensions cannot be routinely established in three-dimensional space.