136 results found
    1. Neuroscience

    Sex differences in cerebellar synaptic transmission and sex-specific responses to autism-linked Gabrb3 mutations in mice

    Audrey A Mercer et al.
    Male and female mice differ in basal cerebellar physiology, including the magnitude of synaptic excitation by metabotropic glutamate receptors, kinetics of synaptic inhibition, intrinsic properties, and responses to autism-linked mutations.
    1. Ecology
    2. Plant Biology
    Arabidopsis illustration

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
    1. Neuroscience

    Vascular control of the CO2/H+-dependent drive to breathe

    Colin M Cleary et al.
    Understanding how loss of CO2/H+ vascular reactivity affects respiratory control may facilitate development of treatments for breathing problems in this population.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genome streamlining in a minute herbivore that manipulates its host plant

    Robert Greenhalgh et al.
    The genome of a tiny tomato pest reveals mechanisms that underlie metazoan genome reduction.
    1. Neuroscience

    Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

    Sthitapranjya Pati et al.
    Enhanced Gq-signaling-mediated activation of forebrain excitatory neurons in postnatal life programs enhanced anxiety-, despair- and schizophrenia-like behavior, recapitulating key aspects of the behavioral consequences of early life adversity.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Cell Biology
    2. Neuroscience

    Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction

    Qi Wang et al.
    Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.
    1. Neuroscience

    Role of the visual experience-dependent nascent proteome in neuronal plasticity

    Han-Hsuan Liu et al.
    A screen of visual-experience induced changes in newly-synthesized proteins in Xenopus optic tectum identifies unexpected candidate plasticity proteins.
    1. Neuroscience

    NPTX2 and cognitive dysfunction in Alzheimer’s Disease

    Mei-Fang Xiao et al.
    Dysfunction of pyramidal neuron-PV interneuron circuits contributes to cognitive failure in Alzheimer's disease.
    1. Neuroscience

    eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons

    Andon N Placzek et al.
    Building on previous work (Huang et al., 2016), we show that translational control by p-eIF2α is a defense mechanism that prevents persistent cocaine-induced synaptic synaptic potentiation underlying compulsive drug seeking.

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