4,119 results found
    1. Developmental Biology

    Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

    Leia C Shuhaibar et al.
    Fibroblast growth factor induces dephosphorylation and inactivation of the NPR2 guanylyl cyclase, thus decreasing cyclic GMP production in growth plate chondrocytes and contributing to FGF-dependent decreases in bone growth.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

    Julia P Steringer et al.
    The first reconstitution of an unconventional secretory mechanism uncovered the molecular mechanism by which Fibroblast Growth Factor 2 is secreted from mammalian cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

    Adam Graham Grieve et al.
    The iRhom2 protein, a catalytically inactive relative of rhomboid proteases, controls inflammation and growth factor signalling by acting as an essential multifunctional regulatory subunit of the cell surface shedding protease TACE (ADAM17).
    1. Cell Biology

    Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex

    Nicole Ann Najor et al.
    A protein interaction screen revealed desmosomes as a scaffold for the COP9 de-neddylating complex, to promote epidermal differentiation by governing the balance of Nedd8 and Ubiquitin modifications on Epidermal Growth Factor Receptor.
    1. Chromosomes and Gene Expression

    The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

    Yuan Zhang et al.
    Transgenic mice with high levels of FGF21 live for longer than wild-type mice and do so without reducing food intake.
    1. Cancer Biology
    2. Cell Biology

    Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator

    Xiang Zhou et al.
    The nerve growth factor receptor (NGFR) protein regulates p53 via two negative feedback mechanisms, which are hijacked by cancer cells.
    1. Developmental Biology
    2. Plant Biology

    The Arabidopsis transcription factor ABIG1 relays ABA signaled growth inhibition and drought induced senescence

    Tie Liu et al.
    Arabidopsis plants slow growth and jettison leaves in response to drought via a mechanism that involves the transcription factor ABIG1.
    1. Developmental Biology

    Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton

    Rui Yue et al.
    A C-type lectin domain protein is an anabolic growth factor that promotes mesenchymal progenitors in the bone marrow to differentiate into bone cells to maintain skeletal bone mass throughout adult life.
    1. Immunology and Inflammation

    The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

    Heather D Marshall et al.
    Differentiation of CD4 T cells into CD4 T follicular helper cells during viral infection in mice is promoted by tumor growth factor beta.

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