575 results found
    1. Chromosomes and Gene Expression

    Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

    Liou Y Sun et al.
    Mice with a mutation that disrupts the release of growth hormone show greatly increased lifespan, which can be further increased by caloric restriction.
    1. Developmental Biology

    Longevity is impacted by growth hormone action during early postnatal period

    Liou Y Sun et al.
    Transient hormonal alterations during early critical developmental periods can have a crucial and long-lasting effect on lifespan in mice.
    1. Chromosomes and Gene Expression

    The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

    Yuan Zhang et al.
    Transgenic mice with high levels of FGF21 live for longer than wild-type mice and do so without reducing food intake.
    1. Plant Biology

    Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

    Katherine Noelani Chang et al.
    The plant hormone ethylene regulates the expression of multiple genes in the model plant Arabidopsis, including those that respond to other hormones.
    1. Evolutionary Biology

    Oral transfer of chemical cues, growth proteins and hormones in social insects

    Adria C LeBoeuf et al.
    The socially exchanged fluid passed mouth-to-mouth during trophallaxis contains molecules that can influence development, potentially mediating communal control of colony phenotypes.
    1. Developmental Biology
    2. Neuroscience

    Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production

    Hector Sandoval et al.
    The dual role of Drosophila Mitofusin in steroid hormone production and cholesterol ester storage, which is evolutionary conserved by the combined expression of the two mammalian Mitofusins, ensures proper synaptic development.
    1. Plant Biology

    Prioritizing plant defence over growth through WRKY regulation facilitates infestation by non-target herbivores

    Ran Li et al.
    A chewing herbivore induced WRKY transcription factor induces jasmonate-dependent defences and supresses gibbererellin-dependent growth, the latter of which renders rice plants more susceptible to secondary infestation by a piercing-sucking herbivore.
    1. Cancer Biology

    Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers

    Ganesh V Raj et al.
    A novel first-in-class small molecule (ERX-11) that interacts with and disrupts the interactome of the estrogen receptor (ER), blocks the growth of ER-positive breast cancers, including those that are resistant to currently approved hormonal agents.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Presence versus absence of CYP734A50 underlies the style-length dimorphism in primroses

    Cuong Nguyen Huu et al.
    CYP734A50 is a heterostyly gene from primroses that underlies the differences in style length between the two forms by degrading growth-promoting hormones in the short styles.

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