4,917 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg et al.
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Developmental Biology

    A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila

    Joana Torres et al.
    A previously unknown oncogenic feature of an embryonic transcription factor was uncovered from transcriptomic analysis of tumors that lack functional Polycomb silencing.
    1. Developmental Biology
    2. Neuroscience

    Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

    Tamsin J Samuels et al.
    Single molecule mRNA imaging uncovers post-transcriptional regulation of myc mRNA, via a cell-intrinsic mechanism allowing individualised control of neural stem cell proliferation during Drosophila brain development.
    1. Genetics and Genomics

    Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height

    Michael Guo et al.
    Epigenetic profiling of femoral growth plate chondrocytes helps whittle-down GWAS height variants to fewer putative functional variants.
    1. Computational and Systems Biology

    Inherent regulatory asymmetry emanating from network architecture in a prevalent autoregulatory motif

    Md Zulfikar Ali et al.
    Network architecture and physiological features of the cell dictate asymmetric gene regulation between a negative autoregulatory TF gene and its target gene.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Point of View: Is cell size a spandrel?

    Ariel Amir
    Analysis of experiments on bacteria suggests that the dependence of cell size on growth rate is not an adaptation but a causal consequence of a regulatory mechanism that controls DNA replication.
    1. Developmental Biology

    The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

    Aynur Kaya-Çopur et al.
    Muscle fiber growth during development is controlled by the Hippo pathway that links the assembly state of the contractile sarcomeres with the transcriptional state of the sarcomeric genes.
    1. Cell Biology
    2. Computational and Systems Biology

    Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast

    Rosemary Yu et al.
    Global gene expression control mechanisms are modeled using a large dataset consisting of absolute-quantitative proteomics, transcriptomics, and partial metabolomics of Saccharomyces cerevisiae at a wide range of growth conditions.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis

    Arne Sahm et al.
    The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.
    1. Cell Biology

    Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

    Roberto Villaseñor et al.
    Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.

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