7,095 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Determining growth rates from bright-field images of budding cells through identifying overlaps

    Julian MJ Pietsch, Alán F Muñoz ... Peter S Swain
    The BABY algorithm by estimating growth rates of individual cells from time-lapse microscopy images will help characterise the diversity in populations of budding cells, particularly differences in fitness.
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg, Nancy Chang ... Marc W Kirschner
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Cell Biology
    2. Computational and Systems Biology

    Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast

    Rosemary Yu, Egor Vorontsov ... Jens Nielsen
    Global gene expression control mechanisms are modeled using a large dataset consisting of absolute-quantitative proteomics, transcriptomics, and partial metabolomics of Saccharomyces cerevisiae at a wide range of growth conditions.
    1. Developmental Biology
    2. Ecology

    Body mass and growth rates predict protein intake across animals

    Stav Talal, Jon F Harrison ... Arianne J Cease
    Protein nutritional requirements decrease predictively with mass throughout ontogeny across the animal kingdom.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Somatic mutation rates scale with time not growth rate in long-lived tropical trees

    Akiko Satake, Ryosuke Imai ... Masahiro Kasahara
    Long-lived tropical trees in Southeast Asia accumulate somatic mutations in a manner that is dependent on time, rather than growth rate.
    1. Computational and Systems Biology

    Resource allocation accounts for the large variability of rate-yield phenotypes across bacterial strains

    Valentina Baldazzi, Delphine Ropers ... Hidde de Jong
    A coarse-grained model of microbial growth coupling fluxes of carbon and energy shows that resource allocation is a major explanatory factor of the observed variability of growth rates and growth yields across different bacterial strains.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

    Vivek V Thacker, Neeraj Dhar ... John D McKinney
    Time-lapse imaging and the modular recreation of host physiology reveal that alveolar epithelial cells, potential permissive infection sites for Mycobacterium tuberculosis, can restrict early bacterial growth via surfactant secretion.
    1. Microbiology and Infectious Disease

    Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

    Camryn Pajon, Marla C Fortoul ... Robert P Smith
    The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.
    1. Computational and Systems Biology

    A unified framework for measuring selection on cellular lineages and traits

    Shunpei Yamauchi, Takashi Nozoe ... Yuichi Wakamoto
    A unified framework for cell lineage statistics enables quantification of fitness landscapes and selection strength for any cellular lineage traits in a model-independent manner, and reveals the contributions of growth heterogeneity to population growth in diverse experimental model systems.
    1. Developmental Biology
    2. Evolutionary Biology

    Ecdysone coordinates plastic growth with robust pattern in the developing wing

    André Nogueira Alves, Marisa Mateus Oliveira ... Christen Kerry Mirth
    Wings achieve plasticity in size while maintaining robust pattern via ecdysone, which elicits graded responses for growth rates and threshold responses for patterning rates, in the fruit fly Drosophila melanogaster.

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