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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

    Nicolas Aznar et al.
    Daple is a guanine nucleotide-exchange factor (GEF) for trimeric G proteins that enables Wnt/Frizzled receptors to transactivate G proteins during non-canonical Wnt signaling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

    Mikel Garcia-Marcos
    Heterotrimeric G-proteins can be switched on not only by G-protein-coupled receptors but also by cytoplasmic proteins, resulting in different signaling mechanisms in cells depending on the specific type of activator.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase

    Brian C Richardson et al.
    A new structure reveals two Arf-GEF regulatory domains form a single structural unit that stimulates Arf-GEF activity.
    1. Cell Biology
    2. Plant Biology

    Delivery of endocytosed proteins to the cell–division plane requires change of pathway from recycling to secretion

    Sandra Richter et al.
    The same membrane trafficking cargo can change pathways mediated by different members of ARF-GEF family of vesicle formation regulators.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

    Stephen R Daley et al.
    A single point mutation in a Ras activator leads to aberrant constitutive mTOR signaling in peripheral T cells that consequently accumulate as abnormal T helper cells and stimulate the production of autoantibodies by B cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A conserved and regulated mechanism drives endosomal Rab transition

    Lars Langemeyer et al.
    Reconstitution of the endosomal Rab cascade reveals that Rab5 binds and activates the Mon1-Ccz1 guanine nucleotide exchange factor, which in turn recruits Rab7 to membranes to drive fusion.
    1. Structural Biology and Molecular Biophysics

    Mechanisms of ribosome stalling by SecM at multiple elongation steps

    Jun Zhang et al.
    Nascent regulatory peptides tune the translation rate through a continuous, dynamic reshaping of the functional center of the ribosome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Lis1 regulates dynein by sterically blocking its mechanochemical cycle

    Katerina Toropova et al.
    Structural and functional studies reveal how a ubiquitous regulator of dynein keeps the microtubule-based motor in a persistent track-bound state.
    1. Cell Biology

    Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases

    Kim Hou Chia et al.
    The Rag-family GTPases, known activators of TOR complex 1 (TORC1), also function as attenuator that prevents deregulated hyperactivation of TORC1 signaling.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The final step of 40S ribosomal subunit maturation is controlled by a dual key lock

    Laura Plassart et al.
    Cryo-EM and functional studies reveal how combined action of proteins RPS26/eS26 and RIO1 allows late precursors to the human small ribosomal particle to be matured into fully translation-competent 40S subunits.