35 results found
    1. Neuroscience

    Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking

    Jillian N Pearring et al.
    Rather than relying on intrinsic intracellular targeting information, the key phototransduction enzyme guanylate cyclase 1 is delivered to the photosensory cilium with the visual pigment rhodopsin.
    1. Evolutionary Biology

    Experimental evolution reveals hidden diversity in evolutionary pathways

    Peter A Lind et al.
    Genetic architecture governs the evolvability of adaptive paths providing a framework for evolutionary forecasting.
    1. Cell Biology
    2. Neuroscience

    Hypoxia: Adapt or avoid

    Ganesh K Kumar
    Insight
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    1. Neuroscience

    Coordinated control of terminal differentiation and restriction of cellular plasticity

    Tulsi Patel, Oliver Hobert
    Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular plasticity via altering the chromatin landscape.
    1. Neuroscience

    Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

    Abigail M Polter et al.
    Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.
    1. Cancer Biology
    2. Cell Biology

    Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

    Benjamin L Ricca et al.
    In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.
    1. Neuroscience

    Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket

    Wendy Wing Sze Yue et al.
    Visual pigments with a longer peak-absorption wavelength or an open chromophore-binding pocket are generally noisier, being more prone to spontaneous activity.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide

    Yingsong Hao et al.
    C. elegans utilizes bacterially produced nitric oxide as a sensory cue to elicit avoidance of pathogenic bacteria.
    1. Developmental Biology
    2. Neuroscience

    Directional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells

    Young Rae Ji et al.
    Emx2 mediates the directional selectivity of neuromasts by regulating hair bundle orientation in hair cells, and by selecting afferent neuronal targets.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

    Ksenya Cohen Katsenelson et al.
    Uncovering a mechanism for how inflammatory signaling is opposed by a phosphatase identifies a potential druggable target to treat E. coli sepsis.

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