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    1. Human Biology and Medicine
    2. Immunology and Inflammation

    TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury

    Salik Hussain et al.
    The response to TLR4 ligands in mice and humans is modulated by TLR5, which participates in the TLR4 signaling complex.
    1. Cell Biology
    2. Genetics and Genomics

    The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response

    Karina Perlaza et al.
    A genetic screen in a unicellular photosynthetic organism uncovers the first essential signaling component in the chloroplast unfolded protein response that relays information from the chloroplast to the nuclear compartment.
    1. Neuroscience

    Causal role for the subthalamic nucleus in interrupting behavior

    Kathryn H Fife et al.
    Activation of the subthalamic nucleus (STN) pauses or disrupts behavior, while STN inhibition reduces the disruptive effects of surprise, indicating that STN activation is both sufficient and necessary for behavioral inhibition.
    1. Neuroscience

    Removal of inhibition uncovers latent movement potential during preparation

    Uday K Jagadisan, Neeraj J Gandhi
    Non-invasive disinhibition of the oculomotor system shows that ongoing preparatory activity in the superior colliculus has movement-generating potential and need not rise to threshold in order to produce a saccade.
    1. Neuroscience

    Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions

    Michael J Goard et al.
    Visual, parietal, and frontal motor cortices play distinct and necessary roles in mapping sensory features to future motor action.
    1. Cancer Biology
    2. Developmental Biology

    Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

    Inês M Tenente et al.
    MYF5 and MYOD regulate rhabdomyosaroma growth and tumor-propagating potential, acting more than as passive markers retained from the target cell-of-origin during transformation.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    The selectivity of the Na+/K+-pump is controlled by binding site protonation and self-correcting occlusion

    Huan Rui et al.
    Computations based on detailed atomic models explain how the ATP-driven sodium-potassium pump avoids transporting the wrong type of ions in order to maintain the physiological concentration of sodium and potassium ions across the cell membrane.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Coordinated hedgehog signaling induces new hair follicles in adult skin

    Xiaoyan Sun et al.
    Hedgehog-pathway activation in adjacent epithelial and stromal cells, but not in epithelial or stromal cells alone, enables the generation of functional de novo hair follicles in unwounded adult mouse skin.
    1. Genetics and Genomics

    Single-amino acid variants reveal evolutionary processes that shape the biogeography of a global SAR11 subclade

    Tom O Delmont et al.
    An in-depth metagenomic analysis of possibly the most abundant and widespread microbial lineage in the surface ocean teases apart evolutionary processes that maintain its genomic heterogeneity and biogeography.
    1. Ecology

    Increasing plant diversity with border crops reduces insecticide use and increases crop yield in urban agriculture

    Nian-Feng Wan et al.
    Plant diversification can make an important contribution to ecological intensification and the sustainable use of associated ecosystem services in an urban ecosystem.