590 results found
    1. Developmental Biology
    2. Neuroscience

    A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans

    Wei Zou et al.
    LECT-2 guides dendrite growth and branching via a unique ligand-receptor complex.
    1. Developmental Biology
    2. Neuroscience

    Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions

    Xintong Dong et al.
    The enzyme KPC-1/Furin down-regulates the DMA-1 receptor in neurons, allowing growing dendrites to migrate away from intermediate targets.
    1. Developmental Biology
    2. Neuroscience

    Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

    Max Koppers et al.
    Multiple axonal guidance receptors control the local and selective translation of mRNAs by binding to ribosomes, specific mRNAs and RNA-binding proteins.
    1. Developmental Biology
    2. Neuroscience

    NMDA receptors control development of somatosensory callosal axonal projections

    Jing Zhou et al.
    NMDAR receptors act in regulating axon guidance of somatosensory callosal projections in early postnatal life and the expression of EPHB2 receptors in target cells.
    1. Developmental Biology
    2. Neuroscience

    Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion

    Karina Chaudhari et al.
    Axon repulsion in response to the midline repellent slit depends on an evolutionary conserved interaction between the Roundabout receptor and the wave regulatory complex.
    1. Developmental Biology

    SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate

    Hugo Ducuing et al.
    A combination of in vivo models and imaging techniques reveals the distribution of guidance cues and their mechanisms of action during commissural axon navigation of intermediate target.
    1. Developmental Biology
    2. Neuroscience

    NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord

    Janelle C Leggere et al.
    Alternative splicing of the Dcc gene, which is controlled by the NOVA RNA-binding proteins, is crucial during neuronal migration and axon guidance.
    1. Developmental Biology
    2. Neuroscience

    Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2

    Verity Johnson et al.
    ROBO isoforms with minute sequence variations have significant and distinct functions in axon guidance.
    1. Neuroscience

    Dystroglycan is a scaffold for extracellular axon guidance decisions

    L Bailey Lindenmaier et al.
    Dystroglycan interacts with multiple partners, including the transmembrane receptor Celsr3, to regulate axon tract formation throughout the developing nervous system.
    1. Developmental Biology
    2. Neuroscience

    Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

    Timothy A Evans et al.
    The Roundabout2 receptor acts non-autonomously to promote commissural axons to cross the midline by antagonizing Slit-dependent axon repulsion.

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