622 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community

    Kevin D'hoe, Stefan Vet ... Jeroen Raes
    Human gut bacteria alter their metabolism in response to each other's presence, which causes their community dynamics to deviate from predictions that are based on mono-culture data.
    1. Ecology
    2. Evolutionary Biology

    Community diversity is associated with intra-species genetic diversity and gene loss in the human gut microbiome

    Naïma Madi, Daisy Chen ... Nandita R Garud
    Longstanding eco-evolutionary theories are tested using shotgun metagenomic data from the human gut microbiome, showing links between community diversity and the evolutionary trajectory of a focal species within the community.
    1. Microbiology and Infectious Disease

    Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides

    Yang Fu, Xiao-Dan Luo ... Wence Wang
    Lactobacillus plantarum regulates host uric acid metabolism via its own nucleoside hydrolase iunH.
    1. Ecology

    Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly

    Inés Martínez, Maria X Maldonado-Gomez ... Jens Walter
    Experiments in ex-germ-free mice establish a measurable effect of colonization history on gut microbiota assembly, illuminating a potential cause for the high levels of unexplained individuality in host-associated microbial communities.
    1. Developmental Biology
    2. Immunology and Inflammation

    Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

    Jennifer C Regan, Mobina Khericha ... Linda Partridge
    In the fruit fly Drosophila melanogaster, stem cell activity ages female guts but not male guts; furthermore, males with feminized guts develop pathologies but gain an increase in lifespan through dietary restriction.
    1. Computational and Systems Biology

    Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics

    Mayank Baranwal, Ryan L Clark ... Ophelia S Venturelli
    Recurrent neural network models enable prediction and design of health-relevant metabolite dynamics in synthetic human gut communities.
    1. Immunology and Inflammation

    IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva

    Katherine M Buckley, Eric Chun Hei Ho ... Jonathan P Rast
    Expression of two highly regulated subfamilies of the complex multigene family encoding IL-17 cytokines in the purple sea urchin are sequentially activated in a larval gut-associated inflammation model and modulate downstream gene expression in the gut epithelium.
    1. Ecology
    2. Evolutionary Biology

    Effects of domestication on the gut microbiota parallel those of human industrialization

    Aspen T Reese, Katia S Chadaideh ... Rachel N Carmody
    Gut microbial signatures of domestication parallel those of industrialization, implicating shared ecological drivers.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation

    Elizabeth R Hughes, Maria G Winter ... Sebastian E Winter
    Bioinformatics analyses and experiments in mouse models reveal how Escherichia coli accesses the molecular hydrogen pool to boost colonization during acute colitis.
    1. Cell Biology
    2. Genetics and Genomics

    Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling

    Priyanka Das, Alejandro Aballay, Jogender Singh
    Calcineurin inhibition has opposing effects on Caenorhabditis elegans lifespan and survival on pathogens via its role in the defecation motor program.

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