Human gut bacteria alter their metabolism in response to each other's presence, which causes their community dynamics to deviate from predictions that are based on mono-culture data.
Longstanding eco-evolutionary theories are tested using shotgun metagenomic data from the human gut microbiome, showing links between community diversity and the evolutionary trajectory of a focal species within the community.
Inés Martínez, Maria X Maldonado-Gomez ... Jens Walter
Experiments in ex-germ-free mice establish a measurable effect of colonization history on gut microbiota assembly, illuminating a potential cause for the high levels of unexplained individuality in host-associated microbial communities.
Jennifer C Regan, Mobina Khericha ... Linda Partridge
In the fruit fly Drosophila melanogaster, stem cell activity ages female guts but not male guts; furthermore, males with feminized guts develop pathologies but gain an increase in lifespan through dietary restriction.
Katherine M Buckley, Eric Chun Hei Ho ... Jonathan P Rast
Expression of two highly regulated subfamilies of the complex multigene family encoding IL-17 cytokines in the purple sea urchin are sequentially activated in a larval gut-associated inflammation model and modulate downstream gene expression in the gut epithelium.
Elizabeth R Hughes, Maria G Winter ... Sebastian E Winter
Bioinformatics analyses and experiments in mouse models reveal how Escherichia coli accesses the molecular hydrogen pool to boost colonization during acute colitis.