123 results found
    1. Microbiology and Infectious Disease

    Lipid hijacking: a unifying theme in vector-borne diseases

    Anya J O'Neal et al.
    A conceptual and unifying framework with a critical appraisal of lipid hijacking by microbes cycling between an arthropod vector and a mammalian host is explored.
    1. Ecology
    2. Microbiology and Infectious Disease

    Global landscape of phenazine biosynthesis and biodegradation reveals species-specific colonization patterns in agricultural soils and crop microbiomes

    Daniel Dar et al.
    Computational approach quantifies the abundance of phenazine-antibiotic producing and biodegrading bacteria in diverse soil and plant-associated habitats.
    1. Microbiology and Infectious Disease

    Biofilms deform soft surfaces and disrupt epithelia

    Alice Cont et al.
    The growth of multicellular bacterial structures called biofilms generates forces that deform soft material substrates and disrupt epithelial cell layers, potentially mechanically damaging host tissue.
    1. Immunology and Inflammation
    2. Neuroscience

    Drainage of inflammatory macromolecules from the brain to periphery targets the liver for macrophage infiltration

    Linlin Yang et al.
    Circulation of molecules from the brain can serve as a rapid mode of communication from the brain to the liver.
    1. Computational and Systems Biology

    Stochastic logistic models reproduce experimental time series of microbial communities

    Lana Descheemaeker, Sophie de Buyl
    Properties of various microbial communities time series, such as the noise color and neutrality, are captured by stochastic generalized Lotka-Volterra equations, even in the absence of interactions.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer systems immunology

    Nathan E Reticker-Flynn, Edgar G Engleman
    Cancer systems immunology is a highly interdisciplinary field that is advancing our ability to understand and predict the complex behavior that orchestrates the interplay between tumors and the immune system.
    1. Immunology and Inflammation

    Resident macrophages acquire innate immune memory in staphylococcal skin infection

    Reinhild Feuerstein et al.
    Resident dermal Mφ are programmed locally, independently of bone-marrow monocytes during Staphylococcus aureus infection, leading to transiently increased resistance, which is limited by a decrease in macrophage life span.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60

    Chun Kew et al.
    The splicing factor RNP-6/PUF60 suppresses immunity by modulating host splicing and transcriptional responses to infection.
    1. Developmental Biology

    Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes

    Laura E Kuil et al.
    Embryonic and definitive macrophages require colony-stimulating factor 1 receptor, whereas non-hematopoietic metaphocytes that resemble macrophages do not, explaining the relative high numbers of putative macrophages in Csf1r-deficient zebrafish.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance

    Rene Niehus et al.
    A data-driven within-host model reveals that different antibiotics are associated with divergent effects on antibiotic resistance carriage and abundance in hospitalised patients, with important implications for antibiotic stewardship.

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