6,892 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Na+/K+ pump interacts with the h-current to control bursting activity in central pattern generator neurons of leeches

    Daniel Kueh et al.
    The dynamic current generated Na+/K+ pump interacts with the h-current to control the bursting activity of oscillator heart interneurons.
    1. Neuroscience

    Characterization of small fiber pathology in a mouse model of Fabry disease

    Lukas Hofmann et al.
    Globotriaosylcermide directly impacts neuronal integrity and ion channel function as potential mechanism underlying small fiber pathology in Fabry disease.
    1. Neuroscience

    Computational models of O-LM cells are recruited by low or high theta frequency inputs depending on h-channel distributions

    Vladislav Sekulić, Frances K Skinner
    The contribution of biophysical ion channels to neuron function can be predicted by taking advantage of an ongoing dialogue between model and experiment.
    1. Structural Biology and Molecular Biophysics

    Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

    Iordan Iordanov et al.
    Invertebrate TRPM2 channels have stable pores but act as chanzymes that hydrolyze their activating ligand ADP ribose (ADPR), whereas vertebrate TRPM2 channels are catalytically dead but undergo pore inactivation.
    1. Neuroscience

    Ionic mechanisms underlying history-dependence of conduction delay in an unmyelinated axon

    Yang Zhang et al.
    Conduction velocity of action potentials in unmyelinated axons depends ultimately on the gating variables of the fast voltage-gated sodium current and can be predicted from the action potential peak and trough voltages.
    1. Neuroscience

    A quantitative theory of gamma synchronization in macaque V1

    Eric Lowet et al.
    Gamma-band synchronization behavior in area V1 was predicted by weakly coupled oscillator principles.
    1. Epidemiology and Global Health
    2. Medicine

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay et al.
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Neuroscience
    2. Physics of Living Systems

    Binocular rivalry reveals an out-of-equilibrium neural dynamics suited for decision-making

    Robin Cao et al.
    The statistics of binocular rivalry at different combinations of image contrast is reproduced quantitatively by competing out-of-equilibrium populations of independent neural assemblies with idealized attractor dynamics.
    1. Computational and Systems Biology
    2. Neuroscience

    Continuous attractors for dynamic memories

    Davide Spalla et al.
    A neural network model with asymmetric synaptic interactions can store and retrieve multiple continuous memory sequences with their temporal structure.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structure of a mitochondrial complex I intermediate from vascular plants

    Maria Maldonado et al.
    The first atomic resolution structure of a mitochondrial respiratory complex from plants provides insight into the assembly and evolution of respiration in autotrophic eukaryotes.

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