273 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distinct and evolutionary conserved structural features of the human nuclear exosome complex

    Piotr Gerlach et al.
    Cryo-EM structure and biochemical characterization of the human nuclear exosome reveals its specific properties with respect to the yeast complex, underscoring the evolutionary conservation of the RNA-channeling mechanisms and hMTR4 helicase recruitment.
    1. Neuroscience

    Endocytosis at the Drosophila blood–brain barrier as a function for sleep

    Gregory Artiushin et al.
    Endocytosis through the Drosophila blood–brain barrier influences and depends upon sleep.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

    Hyun Bong Park et al.
    A new type of hybrid nonribosomal peptide synthetase (NRPS)-like-pteridine synthase biosynthetic pathway has been illuminated via genome mining.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand

    Philipp K Zuber et al.
    Transcription factors can read out both the sequence and the structure of the non-template DNA strand in the transcription bubble, expanding the repertoire of mechanisms to control transcription.
    1. Cell Biology
    2. Neuroscience

    An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis

    Steven J Del Signore et al.
    Autoinhibition allows synaptic endocytic actin regulators to pre-deploy to synaptic membranes at high concentrations and constrains actin assembly to productive events.
    1. Structural Biology and Molecular Biophysics

    Structural mapping of oligomeric intermediates in an amyloid assembly pathway

    Theodoros K Karamanos et al.
    Solution NMR provides structural and kinetic information about oligomers on pathway to amyloid fibrils that are precisely structured but not cytotoxic.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

    Samuel J Modlin et al.
    Fully assembled DNA methylomes from phylogeographically diverse clinical Mycobacterium tuberculosis complex isolates reveals 'intercellular mosaic methylation' as a source of epigenetic diversity.
    1. Cell Biology
    2. Developmental Biology

    SUMO is a pervasive regulator of meiosis

    Nikhil R Bhagwat et al.
    Multi-dimensional global proteomics describes the SUMO-modified proteome during meiosis and reveals novel roles in regulating the key events of meiotic chromosome metabolism.
    1. Medicine

    Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

    Matthew D Keefe et al.
    Neurological pathology and chronic activation of the induced stress response are caused by expression of a truncated EIF2B5 in vanishing white matter disease.

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