28 results found
    1. Medicine

    A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study

    Joachim Linssen et al.
    Distinct haemocytometric parameters, including cell activation markers, combined in a prognostic score may support early identification of COVID-19 patients likely to deteriorate and thus may benefit from ICU admission.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

    Paul Capewell et al.
    African trypanosomes residing within the skin of infected humans represent an important yet overlooked transmissible parasite population that may thwart efforts to eliminate African sleeping sickness.
    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna et al.
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans

    Pille Hallast et al.
    In addition to its academic merits, characterizing the genetic determinants of male (in)fertility and identifying clinically actionable genetic variants can lead to improved diagnosis or even treatment of such conditions.
    1. Chromosomes and Gene Expression

    An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

    Ingrid Ehrmann et al.
    Cell division by meiosis during sperm production depends on expression of an RNA-binding protein that prevents abnormal RNA-processing pathways.
    1. Ecology

    Harbouring public good mutants within a pathogen population can increase both fitness and virulence

    Richard J Lindsay et al.
    Cooperation theory and a novel synthetic infection system provides a mechanistic understanding of why a seemingly successful disease management strategy can have devastating consequences for infected hosts.
    1. Cancer Biology
    2. Computational and Systems Biology

    Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data

    Simon P Hood et al.
    Diagnosing the presence and clinical significance of prostate cancer can be achieved using AI-based analysis of peripheral blood natural killer (NK) cell subset profiles.
    1. Microbiology and Infectious Disease

    Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

    Dennis Klug et al.
    Exchange of the I domain in the Plasmodium surface protein TRAP against evolutionary distant I domains rescues infectivity of sporozoites.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

    Tamara M Sirey et al.
    Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Large domains of heterochromatin direct the formation of short mitotic chromosome loops

    Maximilian H Fitz-James et al.
    Large regions of foreign DNA inserted into mammalian chromosomes assemble into H3K9me3-heterochromatin and result in increased condensin loading with organisation into shorter mitotic chromosome loops than endogenous DNA.

Refine your results by:

Type
Research categories