44 results found
    1. Medicine

    A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study

    Joachim Linssen, Anthony Ermens ... Andre J van der Ven
    Distinct haemocytometric parameters, including cell activation markers, combined in a prognostic score may support early identification of COVID-19 patients likely to deteriorate and thus may benefit from ICU admission.
    1. Ecology
    2. Immunology and Inflammation

    Hematodinium sp. infection does not drive collateral disease contraction in a crustacean host

    Charlotte E Davies, Jessica E Thomas ... Christopher J Coates
    Neither the presence nor the intensity of Hematodinium sp. parasitisation drives co-infection occurrence, severity, or diversity in the ecologically ubiquitous shore crab, Carcinus maenas.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

    Paul Capewell, Christelle Cren-Travaillé ... Annette MacLeod
    African trypanosomes residing within the skin of infected humans represent an important yet overlooked transmissible parasite population that may thwart efforts to eliminate African sleeping sickness.
    1. Immunology and Inflammation

    High-dimensional analysis of intestinal immune cells during helminth infection

    Laura Ferrer-Font, Palak Mehta ... Johannes U Mayer
    A systematic optimization of intestinal digestion protocols allows for the isolation and high-dimensional flow cytometric analysis of intestinal immune cells during murine helminth infection.
    1. Neuroscience

    Endothelin signalling mediates experience-dependent myelination in the CNS

    Matthew Swire, Yuri Kotelevtsev ... Charles ffrench-Constant
    Endothelin signalling, regulated by changes in neuronal activity associated with experience, influences the number of myelin sheaths formed by individual oligodendrocytes.
    1. Ecology

    Harbouring public good mutants within a pathogen population can increase both fitness and virulence

    Richard J Lindsay, Michael J Kershaw ... Ivana Gudelj
    Cooperation theory and a novel synthetic infection system provides a mechanistic understanding of why a seemingly successful disease management strategy can have devastating consequences for infected hosts.
    1. Microbiology and Infectious Disease

    Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis

    Sara Silva Pereira, Mariana De Niz ... Luisa M Figueiredo
    While Trypanosoma congolense is mostly known to cause a chronic wasting disease in animals, a new mouse model shows that acute cerebral trypanosomiasis is triggered by parasite sequestration and infiltration of T helper cells in the brain parenchyma.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

    Lewis Macdonald, Gillian C Taylor ... Andrew J Wood
    Auxin-inducible degradation of CRISPR-tagged endogenous proteins in mice reveals cell-type-specific dependence on the mitotic chromosome condensation proteins.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics

    Emma M Briggs, Catarina A Marques ... Keith R Matthews
    Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.
    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna, Fabrice Uhel ... Molecular Diagnosis and Risk Stratification in Sepsis (MARS) consortium
    Long non-coding RNA profiles as a source of signal in sepsis.

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