Julia Takuno Hespanhol, Daniel Enrique Sanchez-Limache ... Ethel Bayer-Santos
Salmonella antibacterial effectors act on Y-shaped DNA substrates resembling replication forks or transcription bubbles and lead to DNA double-strand breaks.
Dawn Z Eichenfield, Ty Dale Troutman ... Christopher K Glass
Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.
Behavior- or optogenetic-driven activation of a basolateral amygdala projection to the nucleus accumbens enhances infralimbic cortex activity and long-term fear extinction.
Jiang Li, Rebecca E Ruggiero-Ruff ... Meera G Nair
The small macrophage-secreted protein RELMα is a sex-specific protein that protects against diet-induced obesity through regulating the macrophage–eosinophil innate immune axis in the adipose tissue.
Clonal tracing in vivo and quantitative modeling in silico reveal a unique mode of tissue growth and structural remodeling of the biliary system, providing an insight into the cellular basis for robust liver regeneration.
Lilliana Radoshevich, Francis Impens ... Pascale Cossart
The induction of ISG15 during bacterial infection can be independent of Type I Interferons and leads to an increase in the secretion of cytokines known to be critical for bacterial clearance.
Histones bound to lipid droplets inside cells offer protection against bacteria in flies, and possibly mice, thus suggesting a possible new innate immunity pathway.