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    1. Microbiology and Infectious Disease

    Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases

    Julia Takuno Hespanhol, Daniel Enrique Sanchez-Limache ... Ethel Bayer-Santos
    Salmonella antibacterial effectors act on Y-shaped DNA substrates resembling replication forks or transcription bubbles and lead to DNA double-strand breaks.
    1. Chromosomes and Gene Expression

    Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

    Dawn Z Eichenfield, Ty Dale Troutman ... Christopher K Glass
    Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.
    1. Immunology and Inflammation

    Pioneer neutrophils release chromatin within in vivo swarms

    Hannah M Isles, Catherine A Loynes ... Philip M Elks
    Neutrophil swarms form around a single endogenous pioneer neutrophil in vivo, mediated by DNA release from pioneer neutrophils.
    1. Neuroscience

    Amygdala-ventral striatum circuit activation decreases long-term fear

    Susana S Correia, Anna G McGrath ... Ki A Goosens
    Behavior- or optogenetic-driven activation of a basolateral amygdala projection to the nucleus accumbens enhances infralimbic cortex activity and long-term fear extinction.
    1. Immunology and Inflammation

    Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

    Jiang Li, Rebecca E Ruggiero-Ruff ... Meera G Nair
    The small macrophage-secreted protein RELMα is a sex-specific protein that protects against diet-induced obesity through regulating the macrophage–eosinophil innate immune axis in the adipose tissue.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

    Wiebke Nahrendorf, Alasdair Ivens, Philip J Spence
    Malaria remodels the spleen to imprint tolerance and reduce pathology in subsequent infections.
    1. Developmental Biology

    Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling

    Kenji Kamimoto, Kota Kaneko ... Tohru Itoh
    Clonal tracing in vivo and quantitative modeling in silico reveal a unique mode of tissue growth and structural remodeling of the biliary system, providing an insight into the cellular basis for robust liver regeneration.
    1. Microbiology and Infectious Disease

    Severe infections emerge from commensal bacteria by adaptive evolution

    Bernadette C Young, Chieh-Hsi Wu ... Daniel J Wilson
    Life-threatening S. aureus infections emerge from commensal nose bacteria in association with repeatable adaptive evolution.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    ISG15 counteracts Listeria monocytogenes infection

    Lilliana Radoshevich, Francis Impens ... Pascale Cossart
    The induction of ISG15 during bacterial infection can be independent of Type I Interferons and leads to an increase in the secretion of cytokines known to be critical for bacterial clearance.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A novel role for lipid droplets in the organismal antibacterial response

    Preetha Anand, Silvia Cermelli ... Steven P Gross
    Histones bound to lipid droplets inside cells offer protection against bacteria in flies, and possibly mice, thus suggesting a possible new innate immunity pathway.